Anna Skibińska

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Intravesical immunotherapy for carcinoma in situ of the bladder is arguably the most effective form of tumour immunotherapy described to date. Following repeated instillations of BCG organisms into the bladder, large quantities of cytokines are detected in patients' urine. This study concerns the production of IL-1 beta, IL-2, IL-4, IL-6, IL-8, IL-10,(More)
The relative sensitivity of neoplastic cells to DNA damaging agents is a key factor in cancer therapy. In this paper, we show that pretreatment of Burkitt's lymphoma cell lines expressing the c-met protooncogene with hepatocyte growth factor (HGF) protects them from death induced by DNA damaging agents commonly used in tumour therapy. This protection was(More)
The age-related increase in circulating IL-6 levels in humans which has been attributed to a decline in DHEA production by the adrenal gland is currently attracting attention because of its possible relevance to the aetiology and management of a number of age-related clinical disorders. The potential importance of these observations and suggestions has(More)
In order to gain further insight into the potential immunological benefits of oral administration of DHEA we have examined its effects on the constitutive and PHA-inducible expression by human spleen cell suspensions in vitro of IL-6 and IL-2. This was studied at both the mRNA and protein levels. The quantification of specific mRNA was undertaken using(More)
Among the many immunological events associated with successful intravesical bacillus Calmette Guerin (BCG) immunotherapy of bladder cancer is the induction of a wide range of cytokines including the T helper 2 (T(H)2) designated cytokines Interleukin-6 (IL-6) and IL-10, but not IL-4, in the urine of the patients. The aim of this work was to determine if(More)
Estrogens influence morphology of the brain not only in structures linked to reproductive cycle and reproductive behavior but also structure engaged in memory and cognitive functions. Estrogens stimulate synaptogenesis in pyramidal neurons of CA1 field of hippocampus. Increase in the number of spines on apical dendrites in rats occurs in the prostures phase(More)
Stromal elements are major components of lymphoid tissues contributing to both tissue architecture and function. In this study we report on the phenotype and function of fibroblast-like stromal cells obtained from human spleen. These cells express high levels of CD44 and ICAM-1 and moderate levels of VLA-4, VCAM, CD40 and CD21. They fail to express(More)
The microenvironment of secondary lymphoid organs consists of two major populations of cells, the lymphoid cells and a population of stromal cells that contribute to both tissue architecture and function. Interactions of both populations are essential for the development and control of humoral immune responses. In this study, stromal-cell preparations were(More)