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The lipid bilayer is the diffusion barrier of biological membranes. Highly protective membranes such as the blood-brain barrier (BBB) are reinforced by ABC transporters such as P-glycoprotein (MDR1, ABCB1) and multidrug resistance associated proteins (MRPs, ABCCs). The transporters bind their substrates in the cytosolic lipid bilayer leaflet before they(More)
The cross-sectional area, AD, of a compound oriented in an amphiphilic gradient such as the air-water or lipid-water interface has previously been shown to be crucial for membrane partitioning and permeation, respectively. Here, we developed an algorithm that determines the molecular axis of amphiphilicity and the cross-sectional area, ADcalc, perpendicular(More)
Applications to Porous Media: 1. The anomalous adsorbate dynamics at surfaces in porous media studied by NMR methods. The orientational structure factor and Lévy walks 17. Reorientations mediated by translational diffusion as a mechanism for nuclear magnetic relaxation of molecules confined in surface layers 6. Nuclear magnetic relaxation dispersion of(More)
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