Anna Santa Maria

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Ecdysteroids exert many pharmacological effects in mammals (including humans), most of which appear beneficial, but their mechanism of action is far from understood. Whether they act directly and/or after the formation of metabolites is still an open question. The need to investigate this question has gained extra impetus because of the recent development(More)
Uridine diphosphate UDP-glycosyltransferases (UGTs) are detoxification enzymes widely distributed within living organisms. They are involved in the biotransformation of various lipophilic endogenous compounds and xenobiotics, including odorants. Several UGTs have been reported in the olfactory organs of mammals and involved in olfactory processing and(More)
INTRODUCTION This study aims to determine risk factors for the acquisition of HIV, HBV and HCV infections among Injection Drug Users (IDUs) who attended the out-patient clinic of the Department of Pathological Dependence at Bari Hospital in Bari Province (Italy). METHODS The study was conducted in the year 2008 using the information available in the(More)
Discovery of new more selective and potent Histone deacetylase inhibitors is one of the most promising therapeutical approach for tumor growth arrest and proliferation control. Natural cyclotetrapeptide FR235222 (1) from Acremonium sp. was identified as potent immunosuppressant and HDAC inhibitor with low-nanomolar range activity against HDACs Class I and(More)
Preferred crystallographic orientation (texture) in thin films frequently has a strong effect on the properties of the materials and it is important for stable surface properties. Organized molecular films of poly-perfluorodecylacrylate p(PFDA) were deposited by initiated Chemical Vapor Deposition (iCVD). The high tendency of p(PFDA) to crystallize has been(More)
Congenital FVII deficiency is the most frequently encountered defect among the Rare Bleeding Disorders (RBD). Geographical distribution is uneven but it has been described worldwide. Factor FVII Padua (Arg304Gln) is a Type 2 variant with shows FVII activity levels which varies with the origin of the thromboplastin used in the assay system. It is low (less(More)
Trichothecene cytotoxicity of type A (T-2 toxin and HT-2 toxin), type B (deoxynivalenol [DON] and nivalenol [NIV]), and type D (satratoxins G and H) compounds was determined comparatively by using eight permanent human cell lines (Hep-G2, A549, CaCo-2, HEp-2, A204, U937, RPMI 8226, and Jurkat). Viability of cells was measured by a water-soluble tetrazolium(More)
Although microbes are generally found as endophytes in many plant tissues, the plant shoot meristems have been considered virtually sterile. Plant tissue culture, which utilizes mostly the meristems, has nevertheless given numerous references to microbial existence in these tissues. Since the bud-derived tissue cultures of Scots pine (Pinus sylvestris L.)(More)