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Probabilistic topic modeling of text collections is a powerful tool for statistical text analysis. In this tutorial we introduce a novel non-Bayesian approach, called Additive Regularization of Topic Models. ARTM is free of redundant probabilistic assumptions and provides a simple inference for many combined and multi-objective topic models.
Probabilistic topic modeling of text collections has been recently developed mainly within the framework of graphical models and Bayesian inference. In this paper we introduce an alternative semi-probabilistic approach, which we call additive regularization of topic models (ARTM). Instead of building a purely probabilistic generative model of text we(More)
General properties of aging in animals are considered on the basis of the literature evidence and the results obtained by the authors of this paper. The existence of a specific aging mechanism is inferred. The operation of this mechanism is controlled not only by genes but also by particular noncoding genomic sequences with variable structure. The beginning(More)
Probabilistic topic modeling of text collections is a powerful tool for statistical text analysis. Determining the optimal number of topics remains a challenging problem in topic modeling. We propose a simple entropy regularization for topic selection in terms of Additive Regularization of Topic Models (ARTM), a multicriteria approach for combining(More)
Effect of antioxidants--alpha-tocopherol and 2,6-di-tert-butyl-hydroxytoluene (BHT) on 2-methoxypsoralen (8-MOP) photoaddition was investigated. Spectrophotometric experiments have shown that under anaerobic conditions alpha-tocopherol inhibits photodimerization of 8-MOP and photoaddition of 8-MOP to thymine (in 80% ethanol solution). 50% inhibition is(More)
The amount of defects in DNA secondary structure recognized by nuclease S1 and their localization by sequences of various nucleotide composition were studied in relation to the age factor. It was established that a significant twofold increase in defects of DNA secondary structure was observed in hepatic cells of very old (30 months and older) intact mice(More)
The influence of gamma-irradiation and 5-bromo-2'-deoxyuridine (BUDR) on the life span and behaviour (in photoactivity test) of D. melanogaster was studied. It was found that gamma-irradiation resulted in decrease of life span. However the form of survival curves changed only under exposure to doses higher than 500 Gy. Treatment with BUDR distorted the form(More)
We studied lifespan (LS) of Drosophila melanogaster strains HA and BA. The first one was generated by long-term selection for low male sexual activity and features decreased LS as well as the changes in a relatively constant index--coefficient of LS variation. The BA strain was derived from the HA strain by reverse selection and has the mean LS and(More)