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Targeted inhibition of STATs and IRFs as a potential treatment strategy in cardiovascular disease
A pipeline approach is proposed that combines comparative in silico docking of STAT-SH2 and IRF-DBD models with in vitro STAT andIRF activation inhibition validation, as a novel tool to screen multi-million compound libraries and identify specific inhibitors for STATs and IRFs. Expand
Direct Inhibition of IRF-Dependent Transcriptional Regulatory Mechanisms Associated With Disease
Current knowledge of the different IRF-mediated transcriptional regulatory mechanisms are summarized and how they reflect the diverse functions of IRFs in homeostasis and in TLR and IFN signaling are summarized. Expand
STAT1 and IRF8 in Vascular Inflammation and Cardiovascular Disease: Diagnostic and Therapeutic Potential
STAT1- and IRF8-target genes are postulate as promising markers of vascular inflammation, and STAT1 and IRf8 as potential targets for the development of new immunosuppressive and anti-inflammatory agents for the treatment of CVD. Expand
Signal Integration of IFN-I and IFN-II With TLR4 Involves Sequential Recruitment of STAT1-Complexes and NFκB to Enhance Pro-inflammatory Transcription
Co-binding of STAT1-containing transcription factor complexes and NFκB, activated by IFN-I or IFN -II together with LPS, provides a platform for robust transcriptional activation of pro-inflammatory genes. Expand
ID: 243 : Pro-atherogenic roles of STAT1 and IRF8 in cardiovascular disease
Evidence is provided to suggest that in ECs and VSMCs STAT1 and IRF8 orchestrate a platform for cross-talk between IFN γ and TLR4, and to identify a STAT1-dependent gene signature that reflects a proatherogenic state in human atherosclerosis. Expand