Anna O D'Souza

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BACKGROUND Pharmacotherapy constitutes an important adjunct to behavioral therapy for the treatment of overactive bladder (OAB). Tolterodine and oxybutynin are commonly prescribed drugs for OAB treatment that exert their beneficial effect by suppressing bladder muscle contractions. However, high discontinuation rates have been observed for these drugs in(More)
BACKGROUND Exacerbations of COPD contribute to lung function decline and reduced quality of life. Treatment of exacerbations in the hospital setting is costly, but information concerning the component cost drivers of this care is scarce. Our objective was to describe and characterize costs of COPD care in the hospital setting. METHODS Administrative data(More)
BACKGROUND This retrospective cohort study compared the risks of exacerbations and COPD-related healthcare costs between patients with chronic obstructive pulmonary disease (COPD) initiating tiotropium (TIO) alone and patients initiating triple therapy with fluticasone-salmeterol combination (FSC) added to TIO. METHODS Managed-care enrollees who had an(More)
OBJECTIVE To evaluate the clinical and economic burden of COPD patients to Medicaid. STUDY DESIGN Retrospective, observational matched cohort design. METHODS We calculated the incremental costs incurred and medical resources used by COPD patients relative to those without COPD. Data were obtained from 8 Medicaid states during 2003-2007. COPD patients(More)
OBJECTIVES To assess the predictive ability of the ratio of controller-to-total asthma medication in commercially insured and Medicaid patients. STUDY DESIGN Retrospective cohort. METHODS Medical and pharmacy claims were used to identify asthma patients between 2004 and 2006. Ratios were computed during 3-, 6-, and 12-month assessment periods and asthma(More)
OBJECTIVE To see if insulin glargine improves glycemic control in a clinical setting. RESEARCH DESIGN AND METHODS A questionnaire and electronic database were used to assess glycemic parameters for 292 type 1 diabetic subjects taking > or =4 injections per day and receiving glargine as their only long-acting basal insulin for at least 6 months.(More)
The aim of this study was to demonstrate differences in hospitalization outcomes including length-of-stay (LOS), charges, and mortality in congestive heart failure patients using the Healthcare Cost and Utilization Project dataset. Hospitalizations with International Classification of Diseases, Ninth Revision, clinical modification (ICD-9-CM) codes for(More)
PURPOSE To demonstrate the value, from the patient's perspective, of an apodized, diffractive, presbyopia-correcting multifocal intraocular lens (MF-IOL) compared to a conventional monofocal intraocular lens (CM-IOL). SETTING Open-label, multi-site U.S. clinical trial. METHODS A cost-benefit analysis was conducted using cataract patients'(More)
OBJECTIVES To quantify healthcare use and costs associated with chronic obstructive pulmonary disease (COPD) among patients discharged from a COPD-related hospitalization or emergency department (ED) visit on a regimen of fluticasone propionate-salmeterol combination versus other inhaled maintenance therapies. STUDY DESIGN Retrospective cohort study. (More)
OBJECTIVES To examine the impact of timing of maintenance treatment initiation (early vs delayed) on risk of future exacerbations and costs in chronic obstructive pulmonary disease (COPD) patients. STUDY DESIGN Retrospective cohort design using data (January 1, 2003, through June 30, 2009) from a large, US-based integrated pharmacy and medical claims(More)