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Background. Familial combined hyperlipidemia (FCHL), the most common genetic form of hyperlipdemia, is characterized by a strong familial clustering and by premature coronary heart disease. The FCHL locus has been mapped to human chromosome 1q21-q23. This region includes the retinoid X receptor gamma (RXRG), a nuclear factor member of the RXR superfamily,… (More)
OBJECTIVE Systemic Lupus Erythematosus (SLE) and antiphospholipid syndrome (APS) are associated with a high prevalence of atherosclerosis. β2 glycoprotein I (β2GPI) represents a link between autoimmunity and endothelial dysfunction. Recently, β2GPI reactive T cells have been identified; however, their role in atherosclerosis is still under investigation. We… (More)
The precursors of atherogenic dyslipidemia (AD) are not well defined. Therefore, we investigated 62 non-obese, non-diabetic AD and 221 normolipemic children. Anthropometric parameters, blood pressure and biochemical measures were obtained in index children, their parents and all available siblings. The heritability (h(2)) of anthropometric and biochemical… (More)
t was recently reported that individuals affected by famil-ial combined hypolipidemia (FHBL2, OMIM #605019) are either homozygotes or compound heterozygotes for loss-of-function (LOF) mutations in the ANGPTL3 gene. 1 FHBL2 was originally described in a kindred identified because of low plasma total and LDL-cholesterol, 2 but a careful evaluation of affected… (More)
[This corrects the article DOI: 10.1371/journal.pone.0120099.].