Anna-Maija Tolppanen

Learn More
BACKGROUND Previous cohort studies have shown that persons with Alzheimer's disease (AD) have a higher risk of hip fractures but recent data from large representative cohorts is scarce. METHODS We investigated the association between AD and prevalent and incident hip fractures in an exposure-matched cohort study conducted in Finland 2002-2009 (the(More)
BACKGROUND Obesity has been consistently associated with dementia. The role of certain risk factors of dementia may change during life, and the importance of having a life-course perspective has been acknowledged. OBJECTIVE The aim of this study was to investigate the association of midlife and late-life body mass index (BMI) with late-life(More)
CONTEXT Vitamin D status is believed to be best indicated by serum 25-hydroxyvitamin D [25(OH)D; consisting of 25(OH)D₃ and 25(OH)D₂] that are obtained from different sources. Suboptimal vitamin D status is common and associated with adverse health outcomes. OBJECTIVES The objectives were to report the prevalence and risk factors of vitamin D deficiency(More)
BACKGROUND AND AIM The common single nucleotide polymorphism (SNP) in the FTO (fat mass and obesity associated) gene has been consistently associated with an increased risk of obesity. We investigated whether the SNP rs9939609 (T/A) of the FTO is associated with risk factors of cardiovascular diseases (CVD), including serum levels of C - reactive protein(More)
BACKGROUND Higher serum total 25-hydroxyvitamin D (25(OH)D) concentrations have been associated with better lung function and lower risk of allergic disease. 25(OH)D3 constitutes the majority of total 25(OH)D and has been suggested to be more potent than 25(OH)D2. We studied the prospective associations of 25(OH)D2 and 25(OH)D3 with asthma, wheezing,(More)
BACKGROUND Evidence is lacking about outcomes associated with the cumulative use of anticholinergic and sedative drugs in people with Alzheimer's disease (AD). This retrospective cohort study investigated the relationship between cumulative exposure to anticholinergic and sedative drugs and hospitalization and mortality in people with and without AD in(More)
BACKGROUND Databases of prescription drug purchases are now widely used in pharmacoepidemiologic studies. Several methods have been used to generate drug use periods from drug purchases to investigate various aspects; e.g., to study associations between exposure and outcome. Typically, such methods have been fairly simplistic, with fixed assumptions of drug(More)
BACKGROUND There are conflicting findings about analgesic use among persons with cognitive impairment compared to cognitively intact older persons. The objective of our study was to investigate the prevalence of analgesic use in community-dwelling persons with and without Alzheimer's disease (AD), within six months after AD diagnosis and to find out factors(More)
BACKGROUND High serum calcium levels have been associated with cognitive decline in older adults. These associations have not been studied in younger adults. The possible association of vitamin D with cognitive function, independent of calcium, is unknown. METHODS A cross-sectional study of associations of serum ionized calcium and 25-hydroxyvitamin D(More)
BACKGROUND Ghrelin may influence the development of obesity through its role in the control of energy balance, food intake, and regulation of body weight. The effects of ghrelin are mediated via the growth hormone secretagogue receptor (GHSR). METHODOLOGY/PRINCIPAL FINDINGS We genotyped 7 single nucleotide polymorphisms (SNPs) in the GHSR gene and(More)