Anna Machoy-Mokrzyńska

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Total activity of alkaline phosphatase (ALP) in serum represents the sum of activities of some isoenzymes and their numerous isoforms derived from various tissues of the organism. The aim of this work was to separate ALP isoenzymes and their isoforms in rat and human serum, compare the properties of serum ALP isoforms in rats and humans, and determine the(More)
This study was aimed at the evaluation of the relationship between genetic polymorphisms of catechol-O-methyltransferase (COMT) (rs4680:A > G—Val158Met, rs6269:A > G, rs4633:C > T, rs4818:C > G) and pain sensitivity after lumbar discectomy. All patients had one-level symptomatic disc herniation from L3 to S1. The primary data recorded included visual(More)
MINI SUMMARY Animals from areas contaminated by industrial emissions containing fluoride may accumulate it predominantly in hard tissues. Therefore, an analysis was performed for the determination of fluoride content in mandibles and teeth of deer living at large in different areas in Western Pomerania (Poland). Samples of hard tissues obtained with a(More)
The factories processing natural phosphates and apatites in Poland release into the atmosphere considerable amounts of fluorine compounds. Fluoride is known to accumulate in the hard tissues of animals and humans. This paper describes the determination of fluoride in mandibles of deer in the years 1982 and 1990. In recent years, the establishments have(More)
Occasional or suicidal methanol intoxications are a permanent problem for most Poisoning Centers around the World. Therefore it is important to look for new diagnostic and clinical prognostic methods. In the present paper 5 cases of methanol intoxication were analyzed. At first the methanol concentrations in blood and urine were estimated with headspace gas(More)
Thirty male mongrel rabbits were divided into 3 equal groups: (1) controls, (2) animals receiving a high-fat diet (HFD) containing cholesterol and coconut oil, and (3) HFD + lecithin. The experiment lasted 12 weeks. In animals receiving a HFD (group II) the QRS interval (ECG) was significantly prolonged, and the concentration of lipid fractions (except for(More)
Fluorine and aluminum are able to pass through the blood-brain barrier and accumulate in the central nervous system (CNS) of exposed animals. Chronic intoxication is accompanied by behavioral disorders, degenerative changes, and abnormalities of aerobic metabolism of the neurons. Awareness of the role of aluminum in Alzheimer's disease stems from(More)
Alkaline phosphatase (ALP) exists as several isoenzymes and many isoforms present in tissues and serum. The objective of this study was to separate tissue ALP forms in rats and humans and characterise their properties. The materials for the investigation were intestinal, bone, and liver tissue of rats and commercially available human preparations of tissue(More)
BACKGROUND Recent studies have revealed the pivotal role of Th17 cells and interleukin-17 (IL-17) in plaque psoriasis development and treatment outcome. The IL-17 family consists of 6 structurally related cytokines (IL-17A, IL-17B, IL-17C, IL-17D, IL-17E, IL-17F), of which IL-17A and IL-17F mediate similar biological effects. OBJECTIVES The aim of this(More)
INTRODUCTION Selenium is generally recognized as an important antioxidant with numerous biological functions. In spite of intense research during recent years, the role of this microelement needs further elucidation. We therefore decided to use the sodium fluoride (NaF) model of chronic intoxication in rats to determine whether selenium is able to prevent(More)