Anna M. Checkley

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Long-term travellers have a high risk of acquiring malaria, and also of discontinuing malaria prophylaxis. A review by Lin Chen and colleagues addresses the relatively neglected area of malaria prevention in long-term travellers. The essential elements of malaria prevention are discussed: awareness of risk, bite avoidance, chemoprophylaxis, rapid diagnosis,(More)
OBJECTIVES To determine which travellers with malaria are at greatest risk of dying, highlighting factors which can be used to target health messages to travellers. DESIGN Observational study based on 20 years of UK national data. SETTING National register of malaria cases. PARTICIPANTS 25,054 patients notified with Plasmodium falciparum malaria, of(More)
Eosinophilia is a common finding in returning travellers and migrants, and in this group it often indicates an underlying helminth infection. Infections are frequently either asymptomatic or associated with non-specific symptoms, but some can cause severe disease. Here the British Infection Society guidelines group reviews common and serious infectious(More)
The efficacy of Bacillus Calmette-Guerin (BCG) vaccination in protection against pulmonary tuberculosis (TB) is highly variable between populations. One possible explanation for this variability is increased exposure of certain populations to non-tuberculous mycobacteria (NTM). This study used a murine model to determine the effect that exposure to NTM(More)
SETTING Randomised Phase IIB clinical trial. OBJECTIVES To assess whether increasing the dose of rifampicin (RMP) from 10 mg/kg to 15 or 20 mg/kg results in an increase in grade 3 or 4 hepatic adverse events and/or serious adverse events (SAE). METHODS Three hundred human immunodeficiency virus negative patients with newly diagnosed microscopy-positive(More)
It has been suggested that recombinant human IGF-I (rhIGF-I) is a potential therapeutic agent in diabetes mellitus. It is known to have glucose-lowering effects in normal individuals, in patients with non-insulin-dependent diabetes (NIDDM) and in extreme insulin-resistant states. IGF-binding proteins (IGFBPs) have the potential to affect the biological(More)
Immune reconstitution disease (IRD) among HIV infected patients is an adverse consequence of restoration of immune responses during the initial months of antiretroviral treatment (ART). Previously, subclinical infections are ‘‘unmasked’’ or pre-existing opportunistic infections clinically deteriorate. Here we describe an unusual case in which a patient(More)
Tuberculous (TB) meningitis is difficult to diagnose and has a high mortality rate, particularly when presentation is delayed. A diagnostic index developed in Vietnam, an area of low-HIV seroprevalence, has been proposed as a means to differentiate TB meningitis from acute bacterial meningitis using clinical and laboratory features. We applied this index(More)
We describe a case of human African trypanosomiasis with a number of unusual features. The clinical presentation was subacute, but the infection was shown to be due to Trypanosoma brucei rhodesiense. The infection relapsed twice following treatment and the patient developed a melarsoprol-associated encephalopathy. Magnetic resonance imaging (MRI) findings(More)
OBJECTIVE To examine temporal and geographical trends, risk factors, and seasonality of imported vivax malaria in the United Kingdom to inform clinical advice and policy. DESIGN Observational study. SETTING National surveillance data from the UK Public Health England Malaria Reference Laboratory, data from the International Passenger Survey, and(More)