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  • Natalia Lomovskaya, Sharee L. Otten, +8 authors C. Richard Hutchinson
  • Biology, Medicine
  • Journal of bacteriology
  • 1999
  • Doxorubicin-overproducing strains of Streptomyces peucetius ATCC 29050 can be obtained through manipulation of the genes in the region of the doxorubicin (DXR) gene cluster that contains dpsH, theContinue Reading
  • Krishnamurthy Madduri, Jonathan Kennedy, +8 authors C.Richard Hutchinson
  • Biology, Medicine
  • Nature Biotechnology
  • 1998
  • A fermentation method that bypasses the low-yielding semisynthesis of epirubicin (4′-epidoxorubicin) and 4′-epidaunorubicin, important cancer chemotherapy drugs, has been developed for StreptomycesContinue Reading
  • Krishnamurthy Madduri, Francesco Torti, Anna Luisa Colombo, C. Richard Hutchinson
  • Biology, Medicine
  • Journal of bacteriology
  • 1993 (First Published: 1 June 1993)
  • Sequence analysis of a portion of the Streptomyces peucetius daunorubicin biosynthetic gene cluster revealed a complete open reading frame (dnrK) that showed DNA and protein sequence homology toContinue Reading
  • Anna Luisa Colombo, Marco Solinas, +7 authors Luciano Garofano
  • Biology, Medicine
  • Journal of bacteriology
  • 1992 (First Published: 1 March 1992)
  • Two DNA fragments, ric1 and ric2, were isolated from the Streptomyces peucetius 7600 mutant, which produces daunorubicin and doxorubicin, on the basis of their abilities to confer doxorubicin andContinue Reading
  • Anna Luisa Colombo, Nicoletta Crespi-Perellino, Arpad Grein, Anacleto Minghetti, Claudio Spalla
  • Biology
  • Biotechnology Letters
  • 1981 (First Published: 1 February 1981)
  • SummaryA mutant of S. aureofaciens characterized by lower growth and higher tetracycline production than its parent strain is described. The mutant has a limited degree of temperature-sensitivity andContinue Reading