Anna Lo Bue

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OBJECTIVE Obstructive sleep apnea is characterized by increased upper airway collapsibility during sleep. The present study investigated the use of the negative expiratory pressure test as a method to rule out obstructive sleep apnea. METHODS Flow limitation was evaluated in 155 subjects. All subjects underwent a diurnal negative expiratory pressure test(More)
Treatment of obstructive sleep apnea (OSA) by continuous positive airway pressure (CPAP) usually causes a reduction in blood pressure (BP), but several factors may interfere with its effects. In addition, although a high sympathetic activity is considered a major contributor to increased BP in OSA, a relationship between changes in BP and in sympathetic(More)
OBJECTIVES To investigate the usefulness of measuring upper airway collapsibility with a negative expiratory pressure application as a screening test for severe obstructive sleep apnea (OSA). INTRODUCTION OSA is a risk factor for cardiovascular disease, and it may have serious consequences. Its recognition may have important implications during the(More)
METHODS: Flow limitation was evaluated in 155 subjects. All subjects underwent a diurnal negative expiratory pressure test and a nocturnal sleep study. The severity of sleep apnea was determined based on the apneahypopnea index. Flow limitation was assessed by computing the exhaled volume at 0.2, 0.5, and 1.0 s (V0.2, V0.5, and V1.0, respectively) during(More)
BACKGROUND AND PURPOSE There are several primary causes for excessive daytime sleepiness (EDS) and sleep disorders in patients with epilepsy. Up to now, studies in the literature report conflicting data in terms of both prevalence and aetiology. The aim of our study was therefore to evaluate the prevalence of EDS and some sleep disorders in a population of(More)
Salvatore Romano, Adriana Salvaggio, Raquel Pastrello Hirata, Anna Lo Bue, Stefano Picciolo, Luis Vicente Franco de Oliveira, Giuseppe Insalaco I National Research Council of Italy, Institute of Biomedicine and Molecular Immunology ‘‘A. Monroy’’, Palermo Italy. II Universidade Nove de Julho, UNINOVE, Sao Paulo/SP Brasil. III University of Messina A.O.U.(More)
The ability of human prostate cancer cells to metabolize androgens was assessed through administration of physiological concentration (0.5-10 nM) of tritiated testosterone (T) as precursor and one-step analysis of both T degradation and products' formation by reverse-phase HPLC and on-line radioactive detection after either 24 h or 72 h incubation. Overall,(More)
Even if a complete recovery is not an available outcome for Alzheimer disease, it is possibile to improve the clinical symptoms (selfsufficiency, cognitive impairment and behavioral disturbances) with pharmacological and non-pharmacological therapies. The treatment of the patient with dementia is a complex one, that cannot rely only on the use of drugs but(More)
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