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- Nicola Traverso, Roberta Ricciarelli, +5 authors Cinzia Domenicotti
- Oxidative medicine and cellular longevity
- 2013
Glutathione (GSH) plays an important role in a multitude of cellular processes, including cell differentiation, proliferation, and apoptosis, and disturbances in GSH homeostasis are involved in the… (More)
- Barbara Marengo, Mariapaola Nitti, +6 authors Cinzia Domenicotti
- Oxidative medicine and cellular longevity
- 2016
Reactive oxygen species (ROS) and their products are components of cell signaling pathways and play important roles in cellular physiology and pathophysiology. Under physiological conditions, cells… (More)
- Anna Lisa Furfaro, José Raúl Zumba Macay, +7 authors Nicola Traverso
- Free radical biology & medicine
- 2012
Cancer cell survival is known to be related to the ability to counteract oxidative stress, and glutathione (GSH) depletion has been proposed as a mechanism to sensitize cells to anticancer therapy.… (More)
- Stefania Patriarca, Anna Lisa Furfaro, +8 authors Nicola Traverso
- Biogerontology
- 2006
Heme oxygenase 1 (HO-1) expression is recognized as a marker of cellular response to oxidative stress; since ageing is believed to be related to oxidative “wear and tear”, HO-1 may represent a… (More)
- Mariapaola Nitti, Anna Lisa Furfaro, +4 authors Cinzia Domenicotti
- Cellular signalling
- 2010
The role of reactive oxygen species (ROS) in the regulation of signal transduction processes has been well established in many cell types and recently the fine tuning of redox signalling in neurons… (More)
- Anna Lisa Furfaro, Sabrina Piras, +7 authors Mariapaola Nitti
- Biochimica et biophysica acta
- 2014
High-risk neuroblastoma (NB) is characterized by the development of chemoresistance, and bortezomib (BTZ), a selective inhibitor of proteasome, has been proposed in order to overcome drug resistance.… (More)
- Barbara Marengo, Chiara De Ciucis, +7 authors Cinzia Domenicotti
- Cell Death and Disease
- 2013
Neuroblastoma (NB) is the second most common solid pediatric tumor and is characterized by clinical and biological heterogeneity, and stage-IV of the disease represents 50% of all cases. Considering… (More)
- Sabrina Piras, Anna Lisa Furfaro, +4 authors Mariapaola Nitti
- Scientific Reports
- 2017
Neuronal adaptation to oxidative stress is crucially important in order to prevent degenerative diseases. The role played by the Nrf2/HO-1 system in favoring cell survival of neuroblastoma (NB) cells… (More)
- Anna Lisa Furfaro, Nicola Traverso, +4 authors Mariapaola Nitti
- Oxidative medicine and cellular longevity
- 2016
The transcription factor, nuclear factor erythroid 2 p45-related factor 2 (Nrf2), acts as a sensor of oxidative or electrophilic stresses and plays a pivotal role in redox homeostasis. Oxidative or… (More)
- Mariapaola Nitti, Anna Lisa Furfaro, +6 authors Cinzia Domenicotti
- Neuroscience Letters
- 2007
Advanced glycation end product (AGE) accumulation in brain is believed to contribute to neuronal death in several neurodegenerative diseases. Neurons exposed to AGEs undergo oxidative stress, but the… (More)