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STUDY OBJECTIVES The objective of this study is to analyze the influence of a previously reported hPer3 gene-length polymorphism in the delayed sleep-phase syndrome and in morningness-eveningness tendencies at low latitudes in the southern hemisphere. DESIGN We have genotyped a length polymorphism in the hPer3 gene characterized by a short repeat allele(More)
A Clock polymorphism T to C situated in the 3' untranslated region (3'-UTR) has been associated with human diurnal preference. At first, Clock 3111C had been reported as a marker for evening preference. However these data are controversial, and data both corroborating and denying them have been reported. This study hypothesizes that differences in Clock(More)
Inter-individual differences in the phase of the endogenous circadian rhythms have been established. Individuals with early circadian phase are called morning types; those with late circadian phase are evening types. The Horne and Ostberg Morningness-Eveningness Questionnaire (MEQ) is the most frequently used to assess individual chronotype. The(More)
Following the widely accepted therapeutic standard of treatment of HCV infection with parenteral interferon alpha, and encouraged by the author's won good experience with orally administered natural human interferon alpha in low doses (leuHuIFN alpha (ldou)), applied to chronic active HBV hepatitis patients, this form of interferon was given to six randomly(More)
The therapy concept is based on a theory of the immunocorrective effect of orally administered natural human interferon alpha in low doses (leuHuIFN alpha (ldou)), manifolded by the logistic amplification system seated in the oral cavity. Fourteen randomly selected patients with chronic active type B hepatitis, aged 7-59 years, were assigned to treatment.(More)
The treatment conception was based on the theory of immunocorrective activity function of low doses of human interferon alpha (HuIFN alpha) multi-played by logistic amplifier system included in oral cavity. Twelve patients with chronic hepatitis, HBV infected, aged 7-59, were randomly chosen for treatment. Previously they underwent immunosuppression without(More)
Authors present the occurrence of the psychopathologic disorders in the group of 33 patients (23 women and 10 men) with severe hepatic disorders (mostly cirrhotic non-alcoholic). Patients in the 20-69 age range were treated in the Medical Academy in Gdańsk in the years 1989-1993. 15 patients were examined twice at intervals from 6 months to 3 years. Using(More)
OBJECTIVE Since many people with chronic hepatitis C virus (HCV) infection are asymptomatic, the occurrence of HCV infection and the role of risk factors among the health-care workers in Poland is unknown and not yet investigated. METHODS In order to determine the risk of HCV infection with regard to different occupational exposures and medical history,(More)
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