Anna Liber

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A recombinant tandem of mouse/human immunoglobulin (Ig) genes was constructed and inserted in the plasmid pGEM1 under the control of the T7 RNA polymerase promoter. Constant Ig genes of murine origin were replaced with human genomic ones. Isotype IgG1 was changed for IgE. Lymphoid cell line Sp2/0 and CHO (chinese hamster ovary) cells were used for(More)
Liver injury such as hepatomegaly, splenomegaly and various degrees of biochemical abnormalities are quite common in children with collagen vascular diseases. They may be primary or secondary, particularly due to drug therapy (drug toxicity, fatty infiltration), superadded infections, diabetes or overlap with autoimmune hepatitis.
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