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Mutations in the GJB2 gene are associated with hereditary hearing loss. Although most studies of GJB2 mutations have dealt with hearing-impaired patients, there are few reports of the frequency of these mutations in the general population. The purpose of this study is to evaluate the prevalence of GJB2 mutations causing inherited deafness in the general(More)
This study assessed the accuracy of an intragastric method of measuring intra-abdominal pressure (IAP). Prospective sequential study with simultaneous paired measurement of gastric and urinary bladder pressures. Operating theatre, University Teaching Hospital.Patients: 9 patients undergoing laparoscopic cholecystectomy were studied. Intraperitoneal(More)
Co-culture strategies are foundational in cell biology. These systems, which serve as mimics of in vivo tissue niches, are typically poorly defined in terms of cell ratios, local cues and supportive cell-cell interactions. In the stem cell niche, the ability to screen cell-cell interactions and identify local supportive microenvironments has a broad range(More)
p = 0.009), sepsis (χ 2 = 3.7; p = 0.06), renal impairment (χ 2 = 28.3; p = 0.0000001), relaparotomy (χ 2 = 4.1; p = 0.04), and death (χ 2 = 9.7; p = 0.002). This study demonstrated a significant clinical association between increased IAP and abnormal pHi. An abnormally low pHi was associated with poor outcome.
BACKGROUND there is a suggestion that while the age-adjusted incidence of hip fracture in the West may be declining, the incidence may be rising in Asia. OBJECTIVE this study examines the incidence and post-fracture mortality from 2001 to 2009 among the population aged 65 years and over. METHODS hip fracture incidence rates and case-fatality rates among(More)
Epidemiological studies indicate the incidence of asthma is increased in obese and overweight humans. Responses to ozone (O(3)), an asthma trigger, are increased in obese (ob/ob) mice lacking the satiety hormone leptin. The long form of leptin receptor (Ob-R(b)) is required for satiety; mice lacking this receptor (db/db mice) are also substantially obese.(More)
Objective: To study the relationship between interleukin-6 (IL-6), tumour necrosis factor (TNF) and the acute phase protein C-reactive protein (CRP) in patients with fulminant hepatic failure (FHF) and to investigate the potential of peripheral blood mononuclear cells (PBMC) isolated from these patients to stimulate CRP production by isolated human(More)
Objective. To compare the M-COVX and the Deltatrac II metabolic monitors under clinical conditions. Design. Prospective clinical comparison. Setting. A general Intensive Care Unit of a university hospital. Patients. Twenty mechanically ventilated critically ill patients. Interventions. The monitors were compared at FiO2 0.3, 0.5, and 0.7 in each patient(More)
COST containment and efficient resource use have forced anesthesiologists to rethink their management strategies for cardiac surgery. In the late 1970s, when anesthetic practice predominantly involved inhalational anesthesia, it was possible to extubate cardiac surgical patients within a few hours after surgery. However, there was no economic pressure or(More)
BACKGROUND As programs for screening, brief intervention, and referral to treatment (SBIRT) for unhealthy alcohol use disseminate, evidence-based approaches for identifying patients with unhealthy alcohol use and alcohol dependence (AD) are needed. While the National Institute on Alcohol Abuse and Alcoholism Clinician Guide suggests use of a single alcohol(More)