Anna Krarup Keller

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PURPOSE We designed an experimental renal transplantation model and evaluated microdialysis as a detector of induced postoperative ischemia, a feared complication that when caused by vascular thrombosis most often causes renal graft loss. MATERIALS AND METHODS Two microdialysis catheters were placed in the left kidney in 16 pigs, including 1 superficially(More)
PURPOSE Acute vascular thrombosis of the renal artery or vein is a feared and devastating complication after renal operations, especially transplantation. We evaluated microdialysis as a possible new tool for the rapid and reliable detection of renal ischemia in a porcine model. MATERIALS AND METHODS A total of 20 healthy anesthetized pigs were randomized(More)
PURPOSE Vascular complications after renal transplantation causing initially only partial renal ischemia can be difficult to discover in time to save the kidney. Our aims were to design an animal model allowing progressive and stepwise reduction of the arterial renal blood flow (RBF) and to investigate whether microdialysis could detect the subsequent(More)
Renal graft survival has improved over the past years, mainly owing to better immunosuppression. Vascular thrombosis, though rare, therefore accounts for up to one third of early graft loss. We assess current literature on transplantation, identify thrombosis risk factors, and discuss means of avoiding thrombotic events and saving thrombosed grafts. The(More)
INTRODUCTION Little is known about local graft metabolism during warm and cold ischemia before renal transplantation. We sought to characterize local metabolic changes in renal grafts during storage to understand acceptable ischemia time. METHODS Kidneys from 60- or 15-kg pigs were randomized to cold (4°C) or warm (37°C) storage. Local renal graft(More)
Delayed graft function (DGF) complicates approximately 25% of kidney allografts donated after brain death (DBD). Remote ischaemic conditioning (rIC) involves brief, repetitive, ischaemia in a distant tissue in connection with ischaemia/reperfusion in the target organ. rIC has been shown to induce systemic protection against ischaemic injuries. Using a(More)
PURPOSE We sought to determine the reproducibility of magnetic resonance imaging renography using 3 different mathematical models and 2 different approaches to convert the relative signal intensity into quantitative indices. Furthermore, we wanted to examine the influence of fluid intake on the obtained renal parameters. MATERIALS AND METHODS A total of(More)
Delayed graft function after transplantation increases the risk of rejection. Remote ischemic conditioning (rIC) consists of repetitive, brief, non-damaging periods of ischemia in a limb. For reasons not fully understood, rIC protects the target organ against subsequent ischemia-reperfusion injury. Because ischemic endothelium attracts dendritic cells(More)
BACKGROUND The newly transplanted kidney is difficult to monitor with regard to postoperative vascular thrombosis, especially when there is delayed graft function. We evaluated microdialysis as a tool for early ischemia detection in porcine kidneys with delayed graft function early after transplantation. METHODS Sixteen pigs were transplanted with 26-hr(More)
Delayed graft function and primary non-function are serious complications following transplantation of kidneys derived from deceased brain dead (DBD) donors. α-melanocyte stimulating hormone (α-MSH) is a pleiotropic neuropeptide and its renoprotective effects have been demonstrated in models of acute kidney injury. We hypothesized that α-MSH treatment of(More)