Anna-Katharina Wiegers

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Human cytomegalovirus (HCMV), a herpesvirus, is a ubiquitously distributed pathogen that causes severe disease in immunosuppressed patients and infected newborns. Efforts are underway to prepare effective subunit vaccines and therapies including antiviral antibodies. However, current vaccine efforts are hampered by the lack of information on protective(More)
In this report we present the results of a study of the intellectual functioning and cognitive profile of 26 Prader-Willi syndrome (PWS) patients. The mean IQ score was 62.3 (range 39-96). In 13 patients a significant difference between verbal and performance IQ was found. In 10 of them the performance IQ was higher than the verbal. The results of subtest(More)
Human cytomegalovirus (HCMV) infections are life-threating to people with a compromised or immature immune system. Upon adhesion, fusion of the virus envelope with the host cell is initiated. In this step, the viral glycoprotein gB is considered to represent the major fusogen. Here, we present for the first time structural data on the binding of an(More)
In this paper we present data on the cognitive abilities analyzed by systematic, standardized psychometric testing in 18 fra(X) boys who participated in a multicenter, longitudinal study. In the majority of the patients no significant differences were found between verbal and performance intelligence. Higher performance IQ than verbal IQ was found primarily(More)
In this paper we review the data on intelligence in fra(X) males reported up to now in the literature, with special attention to its evolution with age. The available data suggest a decline in intellectual functioning in relation to age. These findings, however, should be interpreted with caution because of sampling and other methodological problems related(More)
In this study clinical and psychological findings are presented in five 49,XXXXY patients. Their degree of mental retardation varied greatly, i.e. from moderately to profoundly retarded. A decline in intelligence performance with age was observed in one boy. Language development was severely retarded with a remarkable discrepancy between language expression(More)
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