Anna-Karin Hamberg

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Numerous studies have investigated causes of warfarin dose variability in adults, whereas studies in children are limited both in numbers and size. Mechanism-based population modelling provides an opportunity to condense and propagate prior knowledge from one population to another. The main objectives with this study were to evaluate the predictive(More)
BACKGROUND Warfarin is the most widely prescribed anticoagulant for the prevention and treatment of thromboembolic events. Although highly effective, the use of warfarin is limited by a narrow therapeutic range combined with a more than ten-fold difference in the dose required for adequate anticoagulation in adults. An optimal dose that leads to a(More)
We would like to bring your attention to an error in the article " Warfarin dose prediction in children using pharmacometric bridging – comparison with published pharmacogenetic dosing algorithms " published in European Journal of Clinical Pharma-cology volume 69, year 2013, pages 1275-1283. The error was purely a typo and has not influenced any of the(More)
AIMS Although genetic, clinical and demographic factors have been shown to explain approximately half of the inter-individual variability in warfarin dose requirement in adults, less is known about causes of dose variability in children. This study aimed to identify and quantify major genetic, clinical and demographic sources of warfarin dose variability in(More)
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