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A multilocus method of estimating mating system parameters in populations is presented that recovers information from classification over multiple loci that single-locus estimators do not detect. It is shown that the multilocus estimator provides a standard of reference (null hypothesis) that can be useful in analyzing the effects of factors such as(More)
Amyloid-[Formula: see text] (A[Formula: see text]) oligomers play a crucial role in Alzheimer's disease due to their neurotoxic aggregation properties. Fibrillar A[Formula: see text] oligomerization can lead to protofilaments and protofilament pairs via oligomer elongation and oligomer association, respectively. Small fibrillar oligomers adopt the(More)
Alzheimer's disease (AD) is the most common form of dementia worldwide. The causative agent in this protein misfolding disease is the 39 to 42-residues long amyloid-b (Ab) peptide, that aggregates into oligomers, filaments, and fibrils found in plaque deposits in the brain of AD patients [1]. Up to now a viable cure for this disease is still not available.(More)
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