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Single-cell patterning and adhesion on chemically engineered poly(dimethylsiloxane) surface.
We demonstrate a new approach to achieve single cell arrays using chemically modified poly(dimethylsiloxane) (PDMS) substrates. Four different microwell geometries (ranging from 10 to 50 microm inExpand
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Instrumentation for medium-throughput two-dimensional capillary electrophoresis with laser-induced fluorescence detection.
In two-dimensional capillary electrophoresis, a sample undergoes separation in the first dimension capillary by sieving electrophoresis. Fractions are periodically transferred across an interfaceExpand
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Rapid Detection of Bacteria from Blood with Surface-Enhanced Raman Spectroscopy.
Traditional methods for identifying pathogens in bacteremic patients are slow (24-48+ h). This can lead to physicians making treatment decisions based on an incomplete diagnosis and potentiallyExpand
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Microfluidic advances in phenotypic antibiotic susceptibility testing
A strong natural selection for microbial antibiotic resistance has resulted from the extensive use and misuse of antibiotics. Though multiple factors are responsible for this crisis, the mostExpand
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Interface of an array of five capillaries with an array of one-nanoliter wells for high-resolution electrophoretic analysis as an approach to high-throughput chemical cytometry.
We report a system that allows the simultaneous aspiration of one or more cells into each of five capillaries for electrophoresis analysis. A glass wafer was etched to create an array of 1-nL wells.Expand
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Rapid Microbial Sample Preparation from Blood Using a Novel Concentration Device
Appropriate care for bacteremic patients is dictated by the amount of time needed for an accurate diagnosis. However, the concentration of microbes in the blood is extremely low in these patientsExpand
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Indium-tin oxide coated microfabricated device for the injection of a single cell into a fused silica capillary for chemical cytometry.
A microfabricated device is described for the capture and injection of a single mammalian cell into a fused silica capillary for subsequent analysis by chemical cytometry. The device consists of aExpand
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Comparison of anti-fouling surface coatings for applications in bacteremia diagnostics.
To accurately diagnose microbial infections in blood, it is essential to recover as many microorganisms from a sample as possible. Unfortunately, recovering such microorganisms depends significantlyExpand
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A novel device for collecting and dispensing fingerstick blood for point of care testing
We have developed a device capable of a) collection of up to 100 μL of fingerstick blood from a single fingerstick by capillary action, and b) dispensing this blood in variable increments set by the user. Expand
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Materials and Surface Properties Optimization to Prevent Biofouling of a Novel Bacterial Concentrator
Abstract Traditionally, bacterial pathogens in the blood have been identified using culture-based methods that can take several days to obtain results. This can lead to physicians making treatmentExpand
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