Anna J James

Learn More
Homeodomain-containing genes of the Dlx family are expressed in the developing basal ganglia. To investigate the role of Dlx genes during development, we studied their cellular localization in primary cultures of embryonic basal telencephalon, and examined the changes in cellular phenotypes resulting from blockade of Dlx-2 expression. Cells containing(More)
Dissociated primary cultures from rat telencephalon at different developmental stages were used to study the effect of basic fibroblast growth factor (FGF2) on Otx2, Dlx1, and Emx1, three homeobox genes expressed in different regions of the developing mammalian forebrain. At embryonic day (E)13.5. the regional pattern of expression of Otx1, Otx2, Dlx1,(More)
BACKGROUND Fibroblasts are implicated in sub-epithelial fibrosis in remodeled asthmatic airways and contribute to airway inflammation by releasing cytokines and other mediators. Fibroblast activity is influenced by members of the leukotriene family of bronchoconstrictor and inflammatory mediators, but it is not known whether human bronchial fibroblasts can(More)
Wavefunctions for the homogeneous electron gas, a germanium pseudo-solid, and a germanium pseudo-atom are optimized using the method of variance minimization. New forms for the Jastrow factor which are convenient to optimize and may be evaluated rapidly are devised and tested and we stress the advantages of using expressions which are linear in the variable(More)
Eosinophils are inflammatory cells of particular relevance to asthma exacerbations. Neuropeptide S (NPS) receptor was identified in a search for asthma susceptibility genes, where the risk haplotypes of the NPS receptor gene associated with total serum IgE above 100IU/ml and asthma. The aim of the present study was to investigate and compare expression of(More)
An important issue in relation to the utility and reliability of biomarkers for asthma monitoring is how asthma is defined and characterized. What kind of asthma, or at what stage of the disease is a particular biomarker supposed to add information? Often, the purpose, or usefulness of a biomarker is not made clear. Diagnosis, severity evaluation, and(More)
BACKGROUND The aim of the study was to investigate how the expression of adhesion molecules changes as neutrophils migrate from the circulation to the lung and if these changes differ between non-smoking subjects and smokers with and without COPD. METHODS Non-smoking healthy subjects (n=22), smokers without (n=21) and with COPD (n=18) were included.(More)
  • R J Needs, G Rajagopal, A J Williamson, L M Fraser, S D Kenny, W M C Foulkes +2 others
  • 2007
We review our recent work on developing and applying quantum Monte Carlo (QMC) methods to electronic systems. The \special k-points" method is introduced into QMC calculations as a method for reducing \independent par-ticle" nite size eeects. We also explain our new formulation of the Coulomb interaction which virtually eliminates so-called Coulomb nite(More)
  • 1