Anna Helander

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Nef is a virulence factor of HIV-1 and other primate lentiviruses that is crucial for rapid progression to AIDS. In cell culture, Nef increases the infectivity of HIV-1 progeny virions by an unknown mechanism. We now show that dynamin 2 (Dyn2), a key regulator of vesicular trafficking, is a binding partner of Nef that is required for its ability to increase(More)
Nef is a virulence factor of HIV-1 and other primate lentiviruses that is crucial for rapid progression to AIDS. Nef modulates the activation state of infected T cells and macrophages, and induces the downregulation of the viral receptor CD4 and of MHC class I molecules. Additionally, Nef increases the intrinsic infectivity of HIV-1 progeny virions by an(More)
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