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MicroRNAs (miRNAs) are a group of small molecules, about twenty nucleotides in length. They are involved in the regulation of gene expression mainly at a posttranscriptional level. This function depends on their complementarity to the 3'UTR regions of mRNAs. MicroRNAs are essential for proper development and functioning of the organism. They are so(More)
Lung cancer (LC) is the most common cause of cancer death in the world. A great challenge in treating NSCLC is the discovery of advanced, molecular tools to diagnose the disease in early stages as well as the development of immunotherapy. MicroRNAs are regulatory molecules (~20 nt in length) with the ability to regulate the expression of genes. The recently(More)
Expression of microRNAs is altered in cancer. Circulating miRNA level assessed in body fluids commonly reflects their expression in tumor cells. In leukemias, however, both leukemic and nonleukemic cells compose circulating miRNA expression profile of peripheral blood. The latter contribution to extracellular miRNA pool may result in specific(More)
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