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Progesterone receptor membrane component-1 (PGRMC1) is present in both the cytoplasm and nucleus of spontaneously immortalized granulosa cells (SIGCs). PGRMC1 is detected as a monomer in the cytoplasm and a DTT-resistant PGRMC1 dimer in the nucleus. Transfected PGRMC1-GFP localizes mainly to the cytoplasm and does not form a DTT-resistant dimer. Moreover,(More)
CONTEXT Progesterone (P4) promotes its own secretion and the survival of human granulosa/luteal (GL) cells. OBJECTIVE The objective of these studies was to determine whether progesterone receptor membrane component-1 (PGRMC1) mediates P4's actions. DESIGN In vitro studies were conducted on GL cells from women undergoing in vitro fertilization and GL5(More)
To determine whether progesterone receptor membrane component 1 (PGRMC1) regulates the development and cisplatin (CDDP)-sensitivity of human ovarian tumors, PGRMC1 was depleted from a human ovarian cancer cell line, dsRed-SKOV-3 cells, using a short hairpin RNA knockdown approach. Compared with parental dsRed-SKOV-3 cells, the PGRMC1-deplete cells grew(More)
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