Anna F Jarman

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Danielle M. Wenner, PhD1,2, Baruch A. Brody, PhD3,2, Anna F. Jarman, BA1, Jacob M. Kolman, MA2,3, Nelda P. Wray, MD MPH1, and Carol M. Ashton, MD MPH1 1The Methodist Hospital Research Institute and Department of Surgery, The Methodist Hospital, 6550 Fannin Street, Houston, TX 77030 2Rice University Department of Philosophy, 6100 Main MS-14, Houston TX(More)
BACKGROUND If trials of therapeutic interventions are to serve society's interests, they must be of high methodological quality and must satisfy moral commitments to human subjects. The authors set out to develop a clinical-trials compendium in which standards for the ethical treatment of human subjects are integrated with standards for research methods. (More)
BACKGROUND Regulatory and professional bodies issue an ever-increasing number of guidance documents on the ethics and methods of clinical trials, but the quality of clinical trials of invasive therapeutic procedures continues to be a concern. We interviewed aspiring and accomplished surgical trialists to understand how they use guidance documents and other(More)
This paper focuses on invasive therapeutic procedures, defined as procedures requiring the introduction of hands, instruments, or devices into the body via incisions or punctures of the skin or mucous membranes performed with the intent of changing the natural history of a human disease or condition for the better. Ethical and methodological concerns have(More)
Utilizing a sorted compendium of international clinical trial standards, investigators identified 15 conflicts among ethical and methodological guidance. Analysis distinguishes interpretational issues, lack of clarity, and contradiction as factors to be addressed if international trial guidance is to be improved.
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