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Online publish-ahead-of-print 23 February 2012 This editorial refers to 'Endothelial-specific Nox2 overex-pression increases vascular superoxide and macrophage recruitment in ApoE 2/2 mice' by G. Douglas et al., pp. 20–29, this issue. Reactive oxygen species (ROS) act as a double-edged sword in numerous cardiovascular conditions. In addition to their known(More)
The ubiquitously expressed aryl hydrocarbon receptor (AhR) induces drug metabolizing enzymes as well as regulators of cell growth, differentiation and apoptosis. Certain AhR ligands promote atherosclerosis, an age-associated vascular disease. Therefore, we investigated the role of AhR in vascular functionality and aging. We report a lower pulse wave(More)
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