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Profiling enzyme activities in vivo using click chemistry methods.

• Anna E. Speers, Benjamin F Cravatt
• Chemistry & biology
• 2004

Methods for profiling the activity of enzymes in vivo are needed to understand the role that these proteins and their endogenous regulators play in physiological and pathological processes. Recently,… (More)

Activity-based protein profiling in vivo using a copper(i)-catalyzed azide-alkyne [3 + 2] cycloaddition.

• Anna E. Speers, Gregory C. Adam, Benjamin F Cravatt
• Journal of the American Chemical Society
• 2003

Toward the goal of assigning function to the tens of thousands of protein products encoded by eukaryotic and prokaryotic genomes, the field of proteomics requires new technologies that can… (More)

Chemical strategies for activity-based proteomics.

• Anna E. Speers, Benjamin F Cravatt
• Chembiochem : a European journal of chemical…
• 2004

The assignment of molecular and cellular functions to the numerous protein products encoded by prokaryotic and eukaryotic genomes presents a major challenge for the field of proteomics. To address… (More)

Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors.

• Daniel A. Bachovchin, Justin T Mohr, +11 authors Benjamin F Cravatt
• Proceedings of the National Academy of Sciences…
• 2011

National Institutes of Health (NIH)-sponsored screening centers provide academic researchers with a special opportunity to pursue small-molecule probes for protein targets that are outside the… (More)

Proteomics of integral membrane proteins--theory and application.

• Anna E. Speers, Christine C. Wu
• Chemical reviews
• 2007

A tandem orthogonal proteolysis strategy for high-content chemical proteomics.

• Anna E. Speers, Benjamin F Cravatt
• Journal of the American Chemical Society
• 2005

The field of proteomics aims to assign functions to the numerous protein products encoded by eukaryotic and prokaryotic genomes. Toward this end, chemical strategies have emerged as a powerful means… (More)

Discovery and optimization of sulfonyl acrylonitriles as selective, covalent inhibitors of protein phosphatase methylesterase-1.

• Daniel A. Bachovchin, Andrea M. Zuhl, +5 authors Benjamin F Cravatt
• Journal of medicinal chemistry
• 2011

The serine hydrolase protein phosphatase methylesterase-1 (PME-1) regulates the methylesterification state of protein phosphatase 2A (PP2A) and has been implicated in cancer and Alzheimer's disease.… (More)

Discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of α/β-hydrolase domain containing 6 (ABHD6).

• K. L. Hsu, Katsunori Tsuboi, +4 authors Benjamin F Cravatt
• Journal of medicinal chemistry
• 2013

α/β-Hydrolase domain containing 6 (ABHD6) is a transmembrane serine hydrolase that hydrolyzes the endogenous cannabinoid 2-arachidonoylglycerol (2-AG) to regulate certain forms of cannabinoid… (More)

Tandem orthogonal proteolysis-activity-based protein profiling (TOP-ABPP)—a general method for mapping sites of probe modification in proteomes

• Eranthie Weerapana, Anna E. Speers, Benjamin F Cravatt
• Nature Protocols
• 2007

Activity-based protein profiling (ABPP) utilizes active site-directed chemical probes to monitor the functional state of enzymes directly in native biological systems. Identification of the specific… (More)

Shotgun analysis of integral membrane proteins facilitated by elevated temperature.

• Anna E. Speers, Adele R. Blackler, Christine C. Wu
• Analytical chemistry
• 2007

The beneficial effects on peak selectivity and resolution of conducting liquid chromatography (LC) at elevated temperature (e.g., 30-80 degrees C) are generally well-known; however, its importance… (More)

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