Anna D’Angelillo

Learn More
Dear Editor, FK506-binding protein (FKBP) 51 is a cochaperone, which belongs to the immunophilin family, a group of proteins with peptidyl-prolyl isomerase activity. FKBPs regulate several biological processes through protein–protein interaction. 1 In particular, FKBP51 is a component of the steroid receptor complex, with a role in steroid resistance; 2(More)
AIMS FK506-binding protein (FKBP) 12 is an inhibitor of transforming growth factor (TGF)-beta type I receptors. Several lines of evidence support the view that TGF-beta stimulates vascular smooth muscle cell (VSMC) proliferation and matrix accumulation. We investigated the effect of FK506, also known as tacrolimus, on cellular proliferation and on matrix(More)
BACKGROUND FKBP51 (FKBP5 Official Symbol) is a large molecular weight component of the family of FK506 binding proteins (FKBP). In recent years, research studies from our laboratory highlighted functions for FKBP51 in the control of apoptosis and melanoma progression. FKBP51 expression correlated with the invasiveness and aggressiveness of melanoma. Since a(More)
Melanoma is the most aggressive skin cancer; its prognosis, particularly in advanced stages, is disappointing largely due to the resistance to conventional anticancer treatments and high metastatic potential. NF-κB constitutive activation is a major factor for the apoptosis resistance of melanoma. Several studies suggest a role for the immunophilin FKBP51(More)
  • 1