Anna Cichonska

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BACKGROUND New treatment options are needed to maintain and improve therapy for tuberculosis, which caused the death of 1.5 million people in 2013 despite potential for an 86 % treatment success rate. A greater understanding of Mycobacterium tuberculosis (M.tb) bacilli that persist through drug therapy will aid drug development programs. Predictive(More)
MOTIVATION A dominant approach to genetic association studies is to perform univariate tests between genotype-phenotype pairs. However, analyzing related traits together increases statistical power, and certain complex associations become detectable only when several variants are tested jointly. Currently, modest sample sizes of individual cohorts, and(More)
metaCCA: summary statistics-based multivariate meta-analysis of genome-wide association studies using canonical correlation analysis Abstract Motivation: A dominant approach to genetic association studies is to perform univariate tests between genotype-phenotype pairs. However, analyzing related traits together increases statistical power, and certain(More)
Annotations created by microarrays producer Affymetrix are based on the genomic and transcriptomic knowledge that was available at a time of construction of a particular chip. However scientific databases are regularly updated so there is a need of performing re-annotation processes. The goal of this work was to assess the relevance of the probes located on(More)
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