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Eating disorders (EDs) are complex psychiatric diseases that include anorexia nervosa and bulimia nervosa, and have higher than 50% heritability. Previous studies have found association of BDNF and NTRK2 to ED, while animal models suggest that other neurotrophin genes might also be involved in eating behavior. We have performed a family-based association(More)
BACKGROUND The study of the human DNA methylome has gained particular interest in the last few years. Researchers can nowadays investigate the potential role of DNA methylation in common disorders by taking advantage of new high-throughput technologies. Among these, Illumina Infinium assays can interrogate the methylation levels of hundreds of thousands of(More)
Autism is a developmental disorder which presents disability in communication and socialisation and a lack of imagination. To promote creativity, exploration and enjoyment in low functioning autistic children that have no verbal communication, we propose MEDIATE, an interactive environment that generates real time visual, aural and vibrotactile stimuli.(More)
Carbon-centered radicals of alcohols commonly used as hydroxyl radical scavengers (MeOH, EtOH, i-PrOH and t-BuOH) add reversibly to histidine with equilibrium constants up to 3 × 10(3) M(-1) and rate constants on the order of 10(9) M(-1) s(-1). Similar equilibria may compromise determinations of one-electron (radical) electrode potentials.
Genomic plasticity of human chromosome 8p23.1 region is highly influenced by two groups of complex segmental duplications (SDs), termed REPD and REPP, that mediate different kinds of rearrangements. Part of the difficulty to explain the wide range of phenotypes associated with 8p23.1 rearrangements is that REPP and REPD are not yet well characterized,(More)
This paper identifies and contextualizes the limitations and problems found in interactive installations that require a massive flux of users. It then presents a set of solutions for these practical problems and shows how they have been applied to a real life installation with exceptionally good results. The application is an interactive water installation(More)
The design of an interactive system for children with severe autism and no verbal communication is one of the most challenging areas a designer of interactive systems can approach; mainly because of the exceptional type of user involved. In fact, this user cannot be typified because autism is not a unique disability but rather a spectrum of disabilities.(More)
The popularization of <i>eCommerce</i> has led to effective customer shopping experiences. Pervasive computing could bring the benefits of eCommerce to brick and mortar stores, merging both online and physical worlds into a unique system. We define <i>crick</i> as the extension of the (c)lick and b(rick) concept, by means of pervasive technologies. In this(More)
Radio Frequency Identification (RFID) offers an extraordinary opportunity to enhance the shopping experience of customers in a retail store. There are two types of possible enhancements: increasing the efficiency of traditional processes, or offering new use cases at the store. RFID offers a great opportunity in both cases. RFID can be used to improve the(More)