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Apart from a single record in a shark, there have been no published studies conducted on Giardia genotypes in fish. The present study investigated the prevalence of Giardia in cultured fingerlings (n=227), wild freshwater (n=227) and wild marine/estuarine species (n=255) of fish in Western Australia by PCR amplification at the 18S rRNA, glutamate(More)
We examined the effects of dexamethasone administration and withdrawal on regional cerebral blood flow (CBF) and the permeability surface area (PS) product for water in the central nervous system of conscious rats. There were no significant changes in CBF. Dexamethasone treatment produced a significant decrease in the PS product for water in the cerebral(More)
Levels of arginine vasopressin have been measured in the blood and cerebrospinal fluid of patients with benign intracranial hypertension and raised intracranial pressure, patients with other neurological diseases and in normal control subjects. There was no difference in blood levels in each of the 3 groups (mean +/- SEM, 2.8 +/- 0.5, 2.5 +/- 0.25, 2.53 +/-(More)
We describe a 34 year old woman who presented initially with a progressive pseudobulbar palsy. A delay of five months occurred before a diagnosis of cerebral systemic lupus erythematosus was made. Currently available investigations for cerebral systemic lupus erythematosus are evaluated and the need for an easily performed specific diagnostic test is(More)
Quinuclidines with a 3-biaryl substituent are a new class of potent, orally active squalene synthase (SQS) inhibitors. Variants around these rigid structures indicate key structural requirements for cationic SQS inhibitors. Thus the lower in vitro potency found for quinuclidines bearing 3-substituents, which did not overlay the biphenyl group of(More)
Ventricular volumes have been measured from CT scans of patients with benign intracranial hypertension both at initial presentation and at a later date. Volumes initially were smaller than normal, but at review five patients showed a significant increase in ventricular size. Persisting small ventricular volume correlated with persisting symptoms and signs(More)
C-terminal binding proteins (CtBPs) are recruited by a variety of transcription factors to mediate gene repression. Nematode CTBP-1 has previously been shown to play a role in the regulation of lifespan; Caenorhabditis elegans strains carrying a deletion in the ctbp-1 gene showed a 10-20% increase in mean and maximal lifespan compared with wild-type control(More)
The volume of the lateral and third ventricles was measured by a non-invasive computerised axial tomographic method in 18 patients presenting with characteristic features of benign intracranial hypertension. Values obtained were significantly lower than in 18 controls matched for age and sex. The demonstration of smaller-than-normal ventricles in benign(More)