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Radioimmunotherapy (RIT) with (131)I-labeled L19SIP (radretumab; a small immunoprotein format antibody directed against the ED-B domain of fibronectin; ∼ 80 kDa molecular weight) has been investigated in several clinical trials. Here, we describe the use of immuno-PET imaging with iodine-124 ((124)I)-labeled L19SIP to predict doses delivered to tumor(More)
Neutrinoless double beta decay is a process that violates lepton number conservation. It is predicted to occur in extensions of the standard model of particle physics. This Letter reports the results from phase I of the Germanium Detector Array (GERDA) experiment at the Gran Sasso Laboratory (Italy) searching for neutrinoless double beta decay of the(More)
We have constructed and operated a 3 ton liquid argon time projection chamber for the R&D programme of the ICARUS project. The chamber has been in operation since May 1991 collecting events from cosmic rays and a monochromatic gamma ray source. We describe the construction of the different detector components and their assembly; we report the solutions(More)
Experiments in underground laboratories have shown evidence of physics beyond the standard model. The anomalies observed in electron-neutrinos from the sun and muon-neutrinos from cosmic rays interactions in the atmosphere can be explained if neutrino are massive and oscillate. The physics program at the INFN Gran Sasso Laboratory that we are defining will(More)
PURPOSE LIFE (non-small cell Lung cancer management In patients progressing after First-linE of treatment in the metastatic setting) is a multicentre Italian observational study, including a cross-sectional and a longitudinal phase, with the aim of describing the therapeutic approach in clinical practice for advanced non-small cell lung cancer (NSCLC)(More)
BACKGROUND Morgagni hernia is a congenital diaphragmatic defect that rarely presents with symptomatic findings in adults. The presence of one diaphragmatic defect may decrease the occurrence of a separate diaphragmatic defect. Appendicitis may be a unique presentation of incarcerated bowel in a Morgagni defect. CASE PRESENTATION Review of recent(More)
Radioimmunotherapy (RIT) with 131 I-labeled L19SIP (radretumab; a small immunoprotein format antibody directed against the ED-B domain of fibronectin; $80 kDa molecular weight) has been investigated in several clinical trials. Here, we describe the use of immuno-PET imaging with iodine-124 (124 I)– labeled L19SIP to predict doses delivered to tumor lesions(More)
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