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Human R1441C LRRK2 regulates the synaptic vesicle proteome and phosphoproteome in a Drosophila model of Parkinson's disease.
It is demonstrated for the first time that the R1441C mutation located within the LRRK2 GTPase domain induces the enhanced phosphorylation of SV proteins in the brain.
The smell of love in Drosophila
- Anna B. Ziegler, Martine Berthelot-Grosjean, Y. Grosjean
- Biology, MedicineFront. Physiol.
- 5 April 2013
Drosophila males have thus developed complementary olfactory strategies to help them to select their mates, and the corresponding neuronal architecture impacting courtship is reviewed.
The Amino Acid Transporter JhI-21 Coevolves with Glutamate Receptors, Impacts NMJ Physiology, and Influences Locomotor Activity in Drosophila Larvae
- Anna B. Ziegler, H. Augustin, +7 authors Y. Grosjean
- Biology, MedicineScientific reports
- 25 January 2016
It is shown that JhI-21 suppresses postsynaptic muscle glutamate receptor abundance, and that JHI- 21 expression in motor neurons regulates larval crawling behavior in a developmental stage-specific manner.
Direct Sensing of Nutrients via a LAT1-like Transporter in Drosophila Insulin-Producing Cells
- G. Manière, Anna B. Ziegler, F. Geillon, D. Featherstone, Y. Grosjean
- Chemistry, MedicineCell reports
- 29 September 2015
Using Ca2+-imaging and ex vivo cultured larval brains, it is demonstrated that IPCs can directly sense extracellular leucine levels via minidiscs (MND), aLeucine transporter, consistent with the idea that MND is necessary for leukine-dependent DILP release.
Activity and coexpression of Drosophila black with ebony in fly optic lobes reveals putative cooperative tasks in vision that evade electroretinographic detection
- Anna B. Ziegler, Florian Brüsselbach, B. Hovemann
- Biology, MedicineThe Journal of comparative neurology
- 15 April 2013
Activity, localization, and strict coexpression with Ebony strongly indicate a specific mode of functional interaction that evades ERG detection, which calls into question the longstanding assumption of Black and Ebony interaction.
Glycerophospholipids - Emerging players in neuronal dendrite branching and outgrowth.
The aim of this review is to provide a general overview about which particular lipids are involved in shaping dendrite morphology during neuronal differentiation, and summarizes recent studies, which helped to gain insights into the mechanisms by which glycerophospholipids and their associated proteins contribute to establishing correct dendritic morphologies.
Cell-Autonomous Control of Neuronal Dendrite Expansion via the Fatty Acid Synthesis Regulator SREBP.
It is revealed that cell-autonomous fatty acid production is required for proper dendritic development and the role of SREBP is established in complex neurons for dendrite elaboration and function.
Lack of Dietary Polyunsaturated Fatty Acids Causes Synapse Dysfunction in the Drosophila Visual System
Modelling the first visual synapse of Drosophila can serve as a simple model to study the effects of PUFAs on synapse function and a similar approach could be further used to screen for genetic factors underlying the molecular mechanisms of synaptic dysfunctions associated with altered PUFA levels.
JhI-21 plays a role in Drosophila insulin-like peptide release from larval IPCs via leucine transport
Drosophila melanogaster is used to shed light on the processes linking dietary leucine intake to insulin secretion and it is shown that knockdown of JhI-21 in IPCs causes malfunction of these cells: they are no longer able to sense dietaryLeucine or to release Dilp2 in a leucaine dependent manner.
Location and functions of Inebriated in the Drosophila eye
Inebriated isoforms express in alternating glial layers of the Drosophila visual system, consistent with a role in histamine recycling in the eye, and its mutants exhibit blue light phototaxis defects.