Anna B. Buchman

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The recent development of a CRISPR-Cas9-based homing system for the suppression of Anopheles gambiae is encouraging; however, with current designs, the slow emergence of homing-resistant alleles is expected to result in suppressed populations rapidly rebounding, as homing-resistant alleles have a significant fitness advantage over functional,(More)
Engineered gene drives - the process of stimulating the biased inheritance of specific genes - have the potential to enable the spread of desirable genes throughout wild populations or to suppress harmful species, and may be particularly useful for the control of vector-borne diseases such as malaria. Although several types of selfish genetic elements exist(More)
Two strategies to control mosquito-borne diseases, such as malaria and dengue fever, are reducing mosquito population sizes or replacing populations with disease-refractory varieties. We propose a genetic system, Semele, which may be used for both. Semele consists of two components: a toxin expressed in transgenic males that either kills or renders(More)
Growing evidence suggests that North American Box Turtles (Terrapene spp.) are declining at an increasing rate. However, there is currently a large gap in our general knowledge of box turtles; thus, baseline demographic and genetic data are needed before a conservation plan can be developed for this group. Therefore, we developed ten microsatellite primers(More)
The largespring Gambusia, Gambusia geiseri, is a stenohaline livebearing fish (Poeciliidae) native to the headwaters of the San Marcos and Comal Rivers, Texas. After introductions for mosquito control (circa 1930), founder populations persisted in several cool water spring systems throughout west Texas, making them invasive and ideal for studies in(More)
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