Anna Bárbara FC Proietti

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HTLV-1 Associated Myelopathy/Tropical spastic paraparesis (HAM/TSP) is the classical neurological syndrome associated with this retrovirus, although other neurological complications are described. We collected data in the neurological and epidemiological databases related of the GIPH cohort, from 1997 and 2012, as well as in the records of the participants.(More)
Since 1997, the Interdisciplinary Research Group on HTLV-1/2 (GIPH) has been following individuals infected with HTLV in Minas Gerais, Brazil, in an open prospective cohort study. The HAM diagnosis is based on clinical parameters, with support of complementary exams to exclude other possible causes of myelopathy. The objective of this study was to evaluate(More)
HTLV-1 is endemic in Brazil and is associated with major illnesses (HAM/TSP, ATL and uveitis). Since the infection remains asymptomatic in the majority of cases and screening is only performed in blood banks, there is an ongoing vertical transmission that remains unnoticed by the public health system. Although recommended by Brazilian researchers of the(More)
Genetic host factors influence the outcome of HTLV-1 infection. Chemokines are important in the immune response against virus, and play a role in HAM/TSP pathogenesis. Duffy antigen receptor for chemokines (DARC) functions as a chemokine reservoir, and DARC polymorphisms rs12075 (A>G; FY*B>FY*A) and rs281477 (-46T>C; FY*B>FY*BES) may influence circulating(More)
HTLV-1-associated myelopathy (HAM) is a classic neurological disease, but cognitive impairment and altered signal intensity on MRI scans of the brain are described in the literature and suggest a more extensive neurological damage. This is a cross-sectional study, conducted between March 17 and September 28, 2012 in the GIPH cohort, Brazil. HAM was(More)
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