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1. To determine industry and regulatory standards established for bioanalytical method validation in support of the estimation and characterization of macromolecules in the preclinical and clinical stages of drug development. 2. To evaluate special validation considerations for quantitative, macromolecule-detecting technologies that have emerged since 1990(More)
We present the case of a 58-year old female with de novo dialysis-dependent acute kidney injury (AKI) secondary to myeloma cast nephropathy. The patient underwent extended high cut-off haemodialysis (HCO-HD), in conjunction with bortezomib-based chemotherapy, and soon became dialysis independent with normal renal function. To our knowledge, this is the(More)
BACKGROUND A single deep inspiration (DI) is known to be a potent bronchodilator but it is not known if repeated DI can accelerate sustained recovery from bronchoconstriction. METHODS We induced sustained bronchoconstriction using increasing concentrations of nebulized methacholine (Mch) during tidal breathing and assessed airway narrowing by measuring(More)
Raising public awareness of organ donation is high on the national agenda, but the magnitude of the challenge is not well clarified. We investigated the attitudes and experience of general practitioners (GPs) regarding organ donation. A survey of 200 GPs working in Ireland revealed that a minority provided donor cards (38%) or displayed information(More)
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