Ann Van Schepdael

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A selective reversed phase liquid chromatography/mass spectrometry (LC/MS(n)) method is described for the identification of erythromycin impurities and related substances in commercial erythromycin samples. Mass spectral data are acquired on a LCQ ion trap mass spectrometer equipped with an electrospray interface operated in positive ion mode. The LCQ is(More)
Benzamycin, combining benzoyl peroxide and erythromycin, is a topical gel used in the treatment of acne vulgaris. Because of the reactivity of benzoyl peroxide, preparations containing both erythromycin and benzoyl peroxide might be unstable and degradation products could be formed. To investigate and identify these latter products, a gradient-based liquid(More)
In this work, thermal desorption-gas chromatography-flame ionization detection (TD-GC-FID) was adapted to enable the determination of residual solvents (RS) in mesoporous silica (MPSi). MPSi is often utilized in various pharmaceutical formulations or drug delivery systems and the accurate determination of RS is an important part of pharmaceutical quality(More)
This review provides systematic coverage of examples in the field of in-capillary electrophorecially mediated microanalysis (EMMA). The recent developments and applications in the time period up to mid 2011 have been described, as well as relevant older papers. The basic principles and modes of in-capillary assays have been demonstrated. An overview is also(More)
A simple, selective, rapid and economical reversed phase high performance liquid chromatographic method for the determination of metformin hydrochloride in bulk and dosage forms has been developed and validated. The separation was carried out on a Discovery reversed phase C-18 column (250 mm x 4.6 mm, 5.0 μm) with UV detection at 233 nm. The mobile phase(More)
s of Lectures and Posters Pharmaceutical and Biomedical Analysis Meeting Utrecht (the Nether lands) , 26 N o v e m b e r 1994 Organizing Committee Prof. Dr. U.A.T. Brinkman (Amsterdam) Dr. J.J.M. Holthuis (Amsterdam) Dr. K. Fnsing (Groningen) H. de Bree (Weesp) Dr. J.E. Paanakker (Oss) Dr. U.R. Tjaden (Leiden) Dr. W. van Bennekom (Utrecht)
of Papers Pharmaceutical and Biomedica Analysis Meeting Tilburg (the Netherlands), 27 November 1992 Organizing committee: Prof. Dr. U.A.T. Bdnkman (Amsterdam) Dr. J.J.M. Holthuis (Amsterdam) Dr. K. Ensing (Groningen) H. De Bree (Weesp) Dr. J.E. Paanakker (Oss) Dr. U.R. Tjaden (Leiden) Dr. R. Woestenborghs (Beerse) THE DETERMINATION OF FK-506 IN WHOLE BLOOD(More)
Aminoglycoside antibiotics are widely used to treat serious Gram-negative and Gram-positive bacterial infections. The lack of a UV chromophore presents a problem in the analysis of aminoglycosides. Derivatization with 1,2-phthalic dicarboxaldehyde (OPA) in the presence of a thiol made it possible to introduce a UV chromophoric thioisoindole moiety. A(More)
A rapid capillary zone electrophoresis method has been developed capable of quantifying 0.05% of R-enantiomer and assaying the main component in escitalopram formulations. Many parameters influencing enantioseparation were investigated, which include chiral selectors, buffer composition and pH, applied voltage, capillary length, temperature, and rinsing(More)