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A genomic biomarker signature can predict skin sensitizers using a cell-based in vitro alternative to animal tests
BackgroundAllergic contact dermatitis is an inflammatory skin disease that affects a significant proportion of the population. This disease is caused by an adverse immune response towards chemicalExpand
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Transcriptional Profiling of Human Dendritic Cell Populations and Models - Unique Profiles of In Vitro Dendritic Cells and Implications on Functionality and Applicability
Background Dendritic cells (DCs) comprise heterogeneous populations of cells, which act as central orchestrators of the immune response. Applicability of primary DCs is restricted due to theirExpand
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The GARD assay for assessment of chemical skin sensitizers.
Allergic contact dermatitis is a skin disease caused by an immunologic reaction to low molecular weight compounds, so called haptens. These substances are commonly present in products used by humansExpand
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Skin sensitizers differentially regulate signaling pathways in MUTZ-3 cells in relation to their individual potency
BackgroundDue to the recent European legislations posing a ban of animal tests for safety assessment within the cosmetic industry, development of in vitro alternatives for assessment of skinExpand
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31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two
About this supplement These abstracts have been published as part of Journal for ImmunoTherapy of Cancer Volume 4 Suppl 1, 2016. The full contents of the supplement are available online atExpand
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Multimodel pathway enrichment methods for functional evaluation of expression regulation.
Functional analysis of quantitative expression data is becoming common practice within the proteomics and transcriptomics fields; however, a gold standard for this type of analysis has yet notExpand
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Prediction of Chemical Respiratory Sensitizers Using GARD, a Novel In Vitro Assay Based on a Genomic Biomarker Signature
Background Repeated exposure to certain low molecular weight (LMW) chemical compounds may result in development of allergic reactions in the skin or in the respiratory tract. In most cases, a certainExpand
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TECHNICAL ADVANCES: A microarray for large‐scale genomic and transcriptional analyses of the zebra finch (Taeniopygia guttata) and other passerines
The microarray technology has revolutionized biological research in the last decade. By monitoring the expression of many genes simultaneously, microarrays can elucidate gene function, as well asExpand
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Evaluation of high throughput gene expression platforms using a genomic biomarker signature for prediction of skin sensitization
BackgroundAllergic contact dermatitis (ACD) develops upon exposure to certain chemical compounds termed skin sensitizers. To reduce the occurrence of skin sensitizers, chemicals are regularlyExpand
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Genome-wide comparison of phage M13-infected vs. uninfected Escherichia coli.
To identify Escherichia coli genes potentially regulated by filamentous phage infection, we used oligonucleotide microarrays. Genome-wide comparison of phage M13-infected and uninfected E. coli, 2Expand
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