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A genomic biomarker signature can predict skin sensitizers using a cell-based in vitro alternative to animal tests

• Henrik Johansson, Malin Lindstedt, Ann-Sofie Albrekt, Carl A. K. Borrebaeck
• BMC Genomics
• 2011

Allergic contact dermatitis is an inflammatory skin disease that affects a significant proportion of the population. This disease is caused by an adverse immune response towards chemical haptens, and… (More)

The GARD assay for assessment of chemical skin sensitizers.

• Henrik Johansson, Ann-Sofie Albrekt, Carl K. A. Borrebaeck, Malin Lindstedt
• Toxicology in vitro : an international journal…
• 2013

Allergic contact dermatitis is a skin disease caused by an immunologic reaction to low molecular weight compounds, so called haptens. These substances are commonly present in products used by humans… (More)

TECHNICAL ADVANCES: A microarray for large-scale genomic and transcriptional analyses of the zebra finch (Taeniopygia guttata) and other passerines.

• Sara Naurin, Staffan Bensch, +5 authors Dennis Hasselquist
• Molecular ecology resources
• 2008

The microarray technology has revolutionized biological research in the last decade. By monitoring the expression of many genes simultaneously, microarrays can elucidate gene function, as well as… (More)

Transcriptional Profiling of Human Dendritic Cell Populations and Models - Unique Profiles of In Vitro Dendritic Cells and Implications on Functionality and Applicability

• Kristina Lundberg, Ann-Sofie Albrekt, +4 authors Malin Lindstedt
• PloS one
• 2013

BACKGROUND Dendritic cells (DCs) comprise heterogeneous populations of cells, which act as central orchestrators of the immune response. Applicability of primary DCs is restricted due to their… (More)

Multimodel pathway enrichment methods for functional evaluation of expression regulation.

• Ufuk Kirik, Paolo Cifani, Ann-Sofie Albrekt, Malin Lindstedt, Anders Heyden, Fredrik Levander
• Journal of proteome research
• 2012

Functional analysis of quantitative expression data is becoming common practice within the proteomics and transcriptomics fields; however, a gold standard for this type of analysis has yet not… (More)

Skin sensitizers differentially regulate signaling pathways in MUTZ-3 cells in relation to their individual potency

• Ann-Sofie Albrekt, Henrik Johansson, Anna Börje, Carl A. K. Borrebaeck, Malin Lindstedt
• BMC Pharmacology and Toxicology
• 2013

Due to the recent European legislations posing a ban of animal tests for safety assessment within the cosmetic industry, development of in vitro alternatives for assessment of skin sensitization is… (More)

Genome-wide comparison of phage M13-infected vs. uninfected Escherichia coli.

• Fredrik Karlsson, Ann-Christin Malmborg-Hager, Ann-Sofie Albrekt, Carl K. A. Borrebaeck
• Canadian journal of microbiology
• 2005

To identify Escherichia coli genes potentially regulated by filamentous phage infection, we used oligonucleotide microarrays. Genome-wide comparison of phage M13-infected and uninfected E. coli, 2… (More)

Prediction of Chemical Respiratory Sensitizers Using GARD, a Novel In Vitro Assay Based on a Genomic Biomarker Signature

• Andy Forreryd, Henrik Johansson, Ann-Sofie Albrekt, Carl K. A. Borrebaeck, Malin Lindstedt
• PloS one
• 2015

BACKGROUND Repeated exposure to certain low molecular weight (LMW) chemical compounds may result in development of allergic reactions in the skin or in the respiratory tract. In most cases, a certain… (More)

Evaluation of high throughput gene expression platforms using a genomic biomarker signature for prediction of skin sensitization

• Andy Forreryd, Henrik Johansson, Ann-Sofie Albrekt, Malin Lindstedt
• BMC Genomics
• 2014

Allergic contact dermatitis (ACD) develops upon exposure to certain chemical compounds termed skin sensitizers. To reduce the occurrence of skin sensitizers, chemicals are regularly screened for… (More)

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