Ann-Marie Pontigon

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BACKGROUND AND PURPOSE For the clinician, the diagnosis of arterial ischemic stroke (AIS) in children is a challenge. Prompt diagnosis of pediatric AIS within 6 hours enables stroke-specific thrombolytic and neuroprotective strategies. METHODS We conducted a retrospective study of prospectively enrolled consecutive cohort of children with AIS, admitted to(More)
Neonatal cerebral sinovenous thrombosis is a frequent contributor to neonatal mortality and morbidity. Treatment is controversial, and reported clinical outcomes vary widely. Newborns with radiologically confirmed neonatal cerebral sinovenous thrombosis from 1992 to 2009 were prospectively followed in our Children's Stroke Clinic for standardized outcomes,(More)
OBJECTIVE Clinical trials are lacking in pediatric cerebral sinovenous thrombosis (CSVT). Neonates and children increasingly receive anticoagulant therapy (ACT) based on adult studies. Safety data for ACT in pediatric CSVT are scant and urgently needed. The objective was to assess the safety and outcome of ACT in pediatric CSVT. METHODS In a single-center(More)
OBJECTIVE Perinatal stroke commonly causes childhood neurological morbidity. Presumed perinatal ischemic stroke (PPIS) defines children presenting outside a normal perinatal period with chronic, focal infarction on neuroimaging. Infarcts are assumed to represent arterial strokes, but recent evidence suggests the periventricular venous infarction (PVI) of(More)
OBJECTIVE To determine whether clinical presentations and risk factor profiles differ between periventricular venous infarction (PVI) and arterial presumed perinatal ischemic stroke (APPIS). DESIGN Retrospective cohort study. PARTICIPANTS A total of 59 children with presumed perinatal ischemic stroke (PPIS) from the SickKids Children's Stroke Program(More)
Pediatric arterial ischemic stroke (AIS) is increasingly diagnosed and carries significant risks of recurrence, morbidity, and mortality. Anticoagulant therapy (ACT) is commonly prescribed in childhood AIS. Hemorrhagic complication rates in pediatric stroke are unknown, and adult safety data are of limited applicability. We analyzed a prospectively enrolled(More)
This population-based study assesses the long-term impact of childhood stroke on function and independence in young adults. We undertook a cross-sectional outcome study of patients with arterial ischemic stroke and cerebral sinovenous thrombosis, beyond 18 years of age. We studied 26 patients; 21 arterial stroke, 5 cerebral sinovenous thrombosis, with 16(More)
AIM To describe outcomes and outcome predictors in childhood basilar artery stroke (BAS). METHOD We prospectively enrolled children with BAS with or without basilar artery occlusion (BAO) in the Toronto Children's Stroke Registry from 1992 to 2009. We assessed presenting features and outcomes including Pediatric Stroke Outcome Measure scores. RESULTS(More)
1Division of Hematology/Oncology, Department of Pediatrics, The Hospital for Sick Children, Toronto, ON; 2Department of Pediatrics, University of Toronto, Toronto, ON; 3Stroke Program, Alberta Children’s Hospital, Pediatric and Clinical Neuroscience, University of Calgary, Calgary, AB; 4Department of Diagnostic Imaging, The Hospital for Sick Children,(More)
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