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Two-component signal transduction.
Most prokaryotic signal-transduction systems and a few eukaryotic pathways use phosphotransfer schemes involving two conserved components, a histidine protein kinase and a response regulator protein.Expand
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Histidine kinases and response regulator proteins in two-component signaling systems.
Phosphotransfer-mediated signaling pathways allow cells to sense and respond to environmental stimuli. Autophosphorylating histidine protein kinases provide phosphoryl groups for response regulatorExpand
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Biological insights from structures of two-component proteins.
Two-component signal transduction based on phosphotransfer from a histidine protein kinase to a response regulator protein is a prevalent strategy for coupling environmental stimuli to adaptiveExpand
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Protein phosphorylation and regulation of adaptive responses in bacteria.
Bacteria continuously adapt to changes in their environment. Responses are largely controlled by signal transduction systems that contain two central enzymatic components, a protein kinase that usesExpand
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Bacterial response regulators: versatile regulatory strategies from common domains.
Response regulators (RRs) comprise a major family of signaling proteins in prokaryotes. A modular architecture that consists of a conserved receiver domain and a variable effector domain enables RRsExpand
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Phosphorylation of bacterial response regulator proteins by low molecular weight phospho-donors.
Bacterial motility and gene expression are controlled by a family of phosphorylated response regulators whose activities are modulated by an associated family of protein-histidine kinases. InExpand
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The catalytic pathway of cytochrome p450cam at atomic resolution.
Members of the cytochrome P450 superfamily catalyze the addition of molecular oxygen to nonactivated hydrocarbons at physiological temperature-a reaction that requires high temperature to proceed inExpand
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Structure of a cholesterol-binding protein deficient in Niemann–Pick type C2 disease
Niemann–Pick disease type C2 (NP-C2) is a fatal hereditary disease characterized by accumulation of low-density lipoprotein-derived cholesterol in lysosomes. Here we report the 1.7-Å resolutionExpand
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Structural relationships in the OmpR family of winged-helix transcription factors.
OmpR, a protein that regulates expression of outer membrane porin proteins in enteric bacteria, belongs to a large family of transcription factors. These transcription factors bind DNA and interactExpand
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Roles of the highly conserved aspartate and lysine residues in the response regulator of bacterial chemotaxis.
The chemotactic responses of bacteria such as Escherichia coli and Salmonella typhimurium are mediated by phosphorylation of the CheY protein. Phospho-CheY interacts with the flagellar motor switchExpand
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