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Takeda G-protein-coupled receptor 5 (TGR5) represents an exciting biological target for the potential treatment of diabetes and metabolic syndrome. A new class of high-throughput screening… (More)
Optimization of a high-throughput screening hit led to the discovery of a new series of 5-phenoxy-1,3-dimethyl-1H-pyrazole-4-carboxamides as highly potent agonists of TGR5. This novel chemotype was… (More)
Reported herein is a medicinal chemistry effort towards the identification of orally available TGR5 agonist 12, which served as a dog tool compound for studies to increase confidence in this… (More)
In this study, the differential breakdown of protein gels containing four types of high and low cross-linked starch granules were studied. Susceptibility to saliva-induced breakdown of starch… (More)
Introduction In the Netherlands, the consumption of fruit and vegetables is too low among children. One of the main reasons is that children often do not like to eat vegetables. In the project… (More)
In deze studie is een inventarisatie gemaakt van mogelijke grondstoffen en technologieen voor de productie van duurzame eiwitproducten voor humane voeding; eiwitproducten die ter vervanging van… (More)