Ann M. Benson

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2(3)-tert-Butyl-4-hydroxyanisole (BHA) is one of several widely used antioxidant food additives that protect against chemical carcinogenesis and toxicity. The present report concerns the enhancement of dicoumarol-inhibited NAD(P)H:quinone reductase [NAD(P)H dehydrogenase (quinone); NAD(P)H:(quinone acceptor) oxidoreductase, EC] activity in mouse(More)
The conjugation of 4-nitroquinoline 1-oxide with GSH by human, rat and mouse liver cytosols, by purified mouse GSH transferases and by extrahepatic organ cytosols of male and female mice was investigated. 4-Nitroquinoline 1-oxide was as effectively conjugated by human liver cytosol as was 1-chloro-2,4-dinitrobenzene, at a substrate concentration of 0.1 mM.(More)
Addition of either 2(3)-tert-butyl-4-hydroxyanlsole (BHA) or I ,2-dlhydro-6-ethoxy-2,2,4-trlmethylquinollne (eth oxyquin) to the diet greatly decreases the bevels of muta genic metabobitesof benzo(a)pyrenein CD-I mice. (R. P. Batzinger, S-V. L. Ou, and E. Bueding, Cancer Res., 38: 000, 1978).The mutagenic activity of the urinary metabo lites of(More)
Investigations in these and other laboratories have estab lished that administration of 2(3)-tert-butyl-4-hydroxyanisole (BHA) to rodents: (a) protects a variety of target tissues against the production of tumors by a wide range of chemical carcin ogens; (b) reduces the levels of mutagenic metabolites pro duced from benzo(a)pyrene and numerous therapeutic(More)
Glutathione S-transferase activities in mouse hepatic cytosols are elevated as much as 11-fold following the administration of BHA (2(3)-tert-butyl-4-hydroxyanisole), a widely used antioxidant food additive. Ethoxyquin (1,2-dihydro-6-ethoxy-2,2,4-trimethylquinoline) and disulfiram [bis(diethyldithiocarbamyl)disulfide] also enhance the activities of(More)
The effects of the dietary administration of four anticarcinogenic sulfur compounds on the activity of DT-diaphorase, a protective enzyme in quinone and quinoneimine detoxification, have been investigated in female CD-1 mice. Bisethylxanthogen, disulfiram, sodium diethyldithiocarbamate, and benzylisothiocyanate, administered at 0.5% of the diet (by weight)(More)
Health promoting nursing practice is seen as the way forward for the nursing profession. This paper outlines the meaning of health promotion and distinguishes between a traditional and new paradigm approach. The research examining the extent to which a new paradigm approach is practised demonstrates that, to date, nurses predominantly adopt the traditional(More)
The development of tumor cell drug resistance is a major obstacle which often leads to failure of cancer chemotherapy. Therefore, reversing the cell drug resistance would have important implications in cancer treatment. We have developed a cisplatin-resistant mouse tumor cell line from the radiation induced fibrosarcoma (RIF-1) parental line; this line is(More)