Ann-Katrin Müller

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Pharmacological enhancement of cholinergic activity following administration of physostigmine is known to induce protective effects generally. However, it is unclear whether the effect of physostigmine on inflammation and acetylcholine (ACh) metabolism is related to different types of surgical intervention or anaesthesia alone. To investigate this, rats(More)
Recent clinical work has questioned the safety of a combined therapy of oral quinidine and intravenous verapamil, because some patients were reported to react with severe hypotension probably due to drug interactions with vascular alpha-adrenergic receptors. In order to obtain further quantitative information on the underlying mechanism, we used the(More)
Animal experiments on 40 Wistar rats show that intraperitoneal application of Varidase can reduce or prevent the formation of adhesions after intra-abdominal interventions. This effect is interpreted as the sequel to a local increase in fibrinolytic activity which leads to the accelerated breakdown of fibrinous pseudo-membranes. The healing of intestinal(More)
In organ cultures the regulation of beta-hCG formation in human placentas of early gestation (EG) and at term (T) was analyzed using the following test substances: dibutyryl cAMP (dbcAMP), theophylline, and by two drugs used to treat patients with premature labor, fenoterol hydrobromide and verapamil hydrochloride. The rapid increase in beta-hCG in culture(More)
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