Ann-Kathrine Granérus

Learn More
Both tau and beta-amyloid 42 (Abeta42) have been implicated in Alzheimer's disease (AD) and tau alone in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). These proteins can be measured in the cerebrospinal fluid (CSF); differences from normal CSF levels may reflect pathophysiological mechanisms. Using ELISAs, we investigated the levels(More)
This community-based study of Parkinson's disease (PD) investigated age at death and cause of death in a cohort of 170 previously studied patients. The current study is a 9-year follow-up, and the results are compared to 510 sex- and age-matched controls from the same area. A total of 170 patients were diagnosed with PD on August 31, 1989, within a defined(More)
The biochemical basis of major depression (MD) in Parkinson’s disease (PD) is largely unknown. To increase our understanding of MD in PD patients, the levels of monoamine metabolites (HVA, 5-HIAA and MHPG), BDNF, orexin-A, IL-6 and corticosterone were examined in cerebrospinal fluid. The analyses were performed in MD patients with (n = 11) and without (n =(More)
Previously we suggested that major depression (MD) in Parkinson’s disease (PD) could be an indication of a more advanced and widespread neurodegenerative process, as PD symptoms were more severe in those with depression. We also found a different antidepressant response with SSRI medication in PD patients with depression compared to depressed patients(More)
Pleural thickening was observed in 4 patients during treatment with bromocriptine in dosages of 10-90 mg/day. Three patients who received at least 50 mg/day developed respiratory symptoms, elevated ESR and pleural effusion, which were normalized after withdrawal of the drug or reduction of the dosage. However, the pleural thickening was not fully reversible(More)
Thirty patients with Parkinson's disease were investigated with regard to their oral health. They had significantly more teeth and less caries than a control group of corresponding age. However, the salivary secretion rate was significantly lower with advancing parkinsonian symptoms. It is concluded that not only motor impairment but also autonomic(More)
Carboxyl labelled l-dopa was administered orally and intravenously to Parkinsonian patients and control subjects. Total radioactivity was measured in the expired air, urine and plasma. The activity in plasma was also measured before and after removal of carbon dioxide-dicarbonate. After intravenous administration about four times more radioactivity was(More)
The intestinal decarboxylation and the absorption of orally administered L-dopa have been studied in 20 parkinsonian patients in different conditions. The decarboxylation generally amounted to 50-70% of the dose given, i.e. only 30-50% of orally administered L-dopa reached the general circulation. The shape of the plasma concentration curve varied(More)