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BACKGROUND Inflammatory bowel disease (IBD) has increased exponentially in industrialized nations over the last 50 years. Previous New Zealand studies have shown that IBD is less common than in other countries; however, clinical observations suggested a high incidence and prevalence of IBD in Canterbury, particularly Crohn's disease (CD). AIM This study(More)
We investigated whether there is an association between cytomegalovirus (CMV) and Epstein-Barr virus (EBV) IgG levels and risk of breast cancer before age 40 years. CMV and EBV IgG levels were measured in stored plasma from 208 women with breast cancer and 169 controls who participated in the Australian Breast Cancer Family Study (ABCFS), a population-based(More)
We reviewed the evidence relating to breast screening using mammography in younger women, primarily those aged 40 to 49. The best evidence comes from the 6 published randomized trials. We performed a metaanalysis, assessing the breast cancer death rates for each year of follow-up in each trial, and producing summary estimates of the cumulative and(More)
Although there are recognized risk factors for breast cancer, its cause is still unknown. It is hypothesized here that breast cancer results from late exposure to a common virus. This hypothesis is investigated by relating the epidemiology of breast cancer to the seroepidemiology of cytomegalovirus, as a surrogate for a breast cancer virus. The hypothesis(More)
Findings of polymerase chain reaction (PCR) studies of cytomegalovirus (CMV) and Epstein-Barr virus (EBV) and breast cancer vary, making it difficult to determine whether either, both, or neither virus is causally associated with breast cancer. We investigated CMV and EBV in paired samples of breast cancer and normal breast tissue from 70 women using(More)
AIMS To investigate factors associated with patient recruitment by general practitioners (GPs) in a randomised controlled trial in primary care. METHODS Cross sectional survey of 100 GPs who had agreed to recruit patients for a randomised controlled trial. A postal questionnaire was sent to the 100 GPs to collect information on factors associated with(More)
AIMS To assess factors influencing attendance or nonattendance at the first round of a population based mammography screening programme, in New Zealand. METHOD Representative samples of women who responded to an invitation to attend screening, and women who did not respond, were interviewed by telephone, by an interviewer independent of the screening(More)
AIMS To investigate the impact of the national breast cancer screening programme, BreastScreen Aotearoa, on breast cancer registrations in New Zealand. METHODS Age-specific breast cancer incidence rates for women aged 50-64 years were compared before and after the establishment of BreastScreen Aotearoa. The degree of spread of breast cancers diagnosed at(More)
BACKGROUND AND AIM The rapid increase in inflammatory bowel disease (IBD) incidence confirms the importance of environment in its etiology. We aimed to assess the role of childhood and other environmental risk factors in IBD. METHODS A population-based case-control study was carried out in Canterbury, New Zealand. Participants comprised 638 prevalent(More)
AIM To examine the incidence of thick melanoma in New Zealand from 1994-2004 and investigate associations with melanoma thickness. METHOD The New Zealand Health Information Service provided information on all registrations for malignant melanoma from 1994-2004. Age-standardised registration rates were calculated. Logistic regression analysis was(More)