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We examined the impact of three lipid lowering drugs on fat oxidation during a 120 minute treadmill walk, at an exercise intensity of 50% maximal oxygen uptake (VO2 max). Subjects (N = 24) were healthy male volunteers with normal serum chemistry, assigned to three groups (n = 8). Group A received simvastatin 20 mg twice daily, Group B received gemfibrozil(More)
OBJECTIVE Previous studies have shown that beta 1 selective agents have fewer adverse effects on exercise metabolism than nonselective beta blockers, and this has been attributed to their reduced blockade of beta 2 receptors. This study aimed at determining whether a beta blocker with partial agonist activity at beta 1 and beta 2 receptors (celiprolol) was(More)
The idea that children might have a contribution to make to decisions about their own welfare is a relatively new one. `Children should be seen but not heard' was a Victorian adage with a familiar ring to those of a certain age! There are fearful examples, even in recent history, of children's views being totally disregarded, as, for example, in the cases(More)
1. Exercise and beta-adrenoceptor blockade have important roles in the prevention and treatment of cardiovascular disease, but fatigue and a reduced capacity to exercise are commonly reported side effects of beta-adrenoceptor blockers. The reduced capacity to exercise may be partly caused by a reduction in fat metabolism. 2. We investigated the effects of(More)
OBJECTIVE To measure the previously reported beta blocker induced adverse changes in mood state and anxiety measures, and to determine if prolonged aerobic exercise attenuates such mood modifications. METHODS After 4 days of drug treatment with comparable doses of propranolol (40 and 80 mg), metoprolol (50 and 100 mg), or placebo, mood (POMS) and anxiety(More)
Aerobic exercise and beta-blocking drugs are regularly prescribed as treatment for hypertension and as a prophylactic for patients at risk from coronary heart disease and for those recovering from an infarct. Some beta blockers, particularly non-beta 1-selective drugs, may make exercise more difficult, possibly by interfering with substrate metabolism(More)
  • Ann Head
  • The British journal of clinical practice
  • 1993
The recent National Fitness Survey has drawn attention to the population's low level of physical (aerobic) fitness and low level of activity. About one-third of middle-aged men and one-half of middle-aged women in England are unfit for continuous walking at a normal pace of about 3 mph. Similar fitness levels were shown for the Welsh population. At the same(More)