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Twenty-six patients underwent a polysomnigraphic study allowing sleep staging and respiratory events scoring with the use of the oronasal flow, abdominal, thoracic and total displacement (Respitracet), and ear oximetry. Moreover the patients were also equipped with a tracheal microphone giving a power rectified envelope (sonospirogram). Eleven patients(More)
OBJECTIVE To determine the diagnostic performance and prognostic value of phosphorylated neurofilament heavy chain (pNfH) and neurofilament light chain (NfL) in CSF as possible biomarkers for amyotrophic lateral sclerosis (ALS) at the diagnostic phase. METHODS We measured CSF pNfH and NfL concentrations in 220 patients with ALS, 316 neurologic disease(More)
15 COPD patients underwent a polysomnographic study demonstrating poor quality of sleep, a mean of SAO2 of 88.8 +/- 3.9% and a apneic-hypopnea index (AHI) of 5.7 +/- 11.8. AHI was higher in sleep stages I and II than in REM sleep. SAO2 showed a progressive drop when going from an awake stage to REM sleep. Respiratory events responsible for the most(More)
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