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Abnormal T cell responses to commensal bacteria are involved in the pathogenesis of inflammatory bowel disease. MyD88 is an essential signal transducer for TLRs in response to the microflora. We hypothesized that TLR signaling via MyD88 was important for effector T cell responses in the intestine. TLR expression on murine T cells was examined by flow(More)
PURPOSE Intestinal trefoil factor (ITF) is a marker of intestinal differentiation that may also play a role in cancer cell biology by inhibiting cell adhesion, promoting cell invasion, and blocking apoptosis. Gastric adenocarcinomas can arise through a process of intestinalization, but no study has yet comprehensively examined the expression of ITF in(More)
BACKGROUND We have previously found that TLR4-deficient (TLR4-/-) mice demonstrate decreased expression of mucosal PGE 2 and are protected against colitis-associated neoplasia. However, it is still unclear whether PGE 2 is the central factor downstream of TLR4 signaling that promotes intestinal tumorigenesis. To further elucidate critical downstream(More)
Bombyx mori presents several types of egg color mutations, all of which have been extensively discussed in sericulture. While the red egg mutation has been previously observed, lethal red-egg mutants have not been reported. In the present work, the red egg mutant Fuyin-lre (Fuyin-lethal red egg) was discovered from the Fuyin germplasm resource of B. mori.(More)
This paper describes DSFS, a decentralized security system for large parallel file system. DSFS stores global access control lists (ACLs) in a centralized decision-making server and pushes pre-authorization lists (PALs) into storage devices. Thus DSFS allows users to flexibly set any access control policy for the global ACL or even change the global ACL(More)
Immunohistochemical studies have indicated that sialylated carbohy drate antigens such as sialvl-In, sialyl-Le", and sialyl-Le" are expressed in a tumor-associated fashion in human colon. Since sialic acid residues are 0-acetylated more extensively in normal colonie epithelium than in colon cancer cells, we examined whether deacetylation of colonie tissues(More)
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