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To serve users quickly, Web service providers build infrastructure closer to clients and use multi-stage transport connections. Although these changes reduce client-perceived round-trip times, TCP's current mechanisms fundamentally limit latency improvements. We performed a measurement study of a large Web service provider and found that, while connections(More)
To answer user queries efficiently, a stream management system must handle continuous, high-volume, possibly noisy, and time-varying data streams. One major research area in stream management seeks to allocate resources (such as network bandwidth and memory) to query plans, either to minimize resource usage under a precision requirement, or to maximize(More)
There have been a number of recent proposals for distributed monitoring infrastructures. We argue that a vital missing component from these proposals is a distributed triggering mechanism, by which nodes in the system can proactively work together to maintain invariants and constraints over the system-wide behavior. Without such a triggering component ,(More)
A distributed data-stream architecture finds application in sensor networks for monitoring environment and activities. In such a network, large numbers of sensors deliver continuous data to a central server. The rate at which the data is sampled at each sensor affects the communication resource and the computational load at the central server. In this(More)
—Three-dimensional (3D) interconnection technology offers several electrical advantages, including reduced signal delay, reduced interconnect power, and design flexibility. 3D integration relies on through-silicon vias (TSVs) and the bonding of multiple active layers to stack several die or wafers containing integrated circuits (ICs) and provide direct(More)
During intracellular membrane trafficking and remodeling, protein complexes known as the ESCRTs (endosomal sorting complexes required for transport) interact with membranes and are required for budding processes directed away from the cytosol, including the budding of intralumenal vesicles to form multivesicular bodies; for the budding of some enveloped(More)
Proteins perform most cellular functions in macromolecular complexes. The same protein often participates in different complexes to exhibit diverse functionality. Current ensemble approaches of identifying cellular protein interactions cannot reveal physiological permutations of these interactions. Here we describe a single-molecule pull-down (SiMPull)(More)
A-kinase anchoring proteins (AKAPs) tether the cAMP-dependent protein kinase (PKA) to intracellular sites where they preferentially phosphorylate target substrates. Most AKAPs exhibit nanomolar affinity for the regulatory (RII) subunit of the type II PKA holoenzyme, whereas dual-specificity anchoring proteins also bind the type I (RI) regulatory subunit of(More)